二氧化硅负载MTSA催化剂合成5-取代1h -四唑的绿色化学方法

D. Mahajan, Dipesh Mistry
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引用次数: 0

摘要

以三聚氰胺三磺酸为异相催化剂,以有机腈和叠氮化钠为原料,在回流DMF中通过[2+3]环加成反应合成5-取代1h -四唑,开发了简单、经济、环保的工艺方案。相应的5-取代1h -四唑收率较低,但使用二氧化硅负载的MTSA时,收率在6 h内达到85%。反应完成后,通过过滤回收催化剂并重复使用,在相同的反应条件下,活性仅略有下降。各种脂肪腈和芳香族腈在相应的5-取代1h -四唑中转化,收率高,无污染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Silica Supported MTSA Catalyst for the Synthesis of 5-Substituted-1H-tetrazole- A Green Chemistry Approach
We have developed simple, cost efficient and environmentally benign protocol for the synthesis of 5-substituted 1H-tetrazole via [2+3] cyclo addition reaction from organic nitrile and sodium azide in refluxing DMF by using heterogeneous catalyst as MTSA (Melamine tri sulphonic acid). The corresponding 5-substituted 1H-tetrazole were obtained in lower yield but when using silica supported MTSA the yield obtained 85% in 6 h. After completion of the reaction, the catalyst was recovered by filtration and reused with only a slight decrease of activity observed under the same reaction conditions. Various aliphatic and aromatic nitrile converted in corresponding 5-substituted 1H-tetrazole in excellent yield without any contamination.
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