原发性高血压与18q染色体的连锁关系

K. Kristjánsson, A. Manolescu, A. Kristinsson, T. Hardarson, H. Knudsen, Sigurdur Ingason, G. Thorleifsson, M. Frigge, A. Kong, J. Gulcher, K. Stefánsson
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引用次数: 101

摘要

我们使用904个微卫星标记进行了全基因组扫描,研究对象为120个冰岛扩展家族490名高血压患者。通过将冰岛大学医院高血压门诊的高血压患者名单与整个冰岛民族的家谱数据库交叉匹配,确定了这些家庭。添加5个标记后,我们发现与18q染色体的连锁,等位基因共享LOD评分为4.60 (P =2.1× 10−6)。这些结果为在18q染色体上发现原发性高血压的新易感基因提供了证据,并表明无需按亚表型分层来研究原发性高血压的遗传学是可能的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Linkage of Essential Hypertension to Chromosome 18q
We performed a genomewide scan with 904 microsatellite markers using 120 extended Icelandic families with 490 hypertensive patients. The families were identified by cross-matching a list of hypertensive patients from the Hypertension Clinic of the University Hospital (Landspitalinn) in Iceland with a genealogy database of the entire Icelandic nation. After adding 5 markers, we found linkage to chromosome 18q with an allele-sharing LOD score of 4.60 (P =2.1× 10−6). These results provide evidence for a novel susceptibility gene for essential hypertension on chromosome 18q and show that it is possible to study the genetics of essential hypertension without stratifying by subphenotypes.
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