K. Kristjánsson, A. Manolescu, A. Kristinsson, T. Hardarson, H. Knudsen, Sigurdur Ingason, G. Thorleifsson, M. Frigge, A. Kong, J. Gulcher, K. Stefánsson
{"title":"原发性高血压与18q染色体的连锁关系","authors":"K. Kristjánsson, A. Manolescu, A. Kristinsson, T. Hardarson, H. Knudsen, Sigurdur Ingason, G. Thorleifsson, M. Frigge, A. Kong, J. Gulcher, K. Stefánsson","doi":"10.1161/01.HYP.0000018580.24644.18","DOIUrl":null,"url":null,"abstract":"We performed a genomewide scan with 904 microsatellite markers using 120 extended Icelandic families with 490 hypertensive patients. The families were identified by cross-matching a list of hypertensive patients from the Hypertension Clinic of the University Hospital (Landspitalinn) in Iceland with a genealogy database of the entire Icelandic nation. After adding 5 markers, we found linkage to chromosome 18q with an allele-sharing LOD score of 4.60 (P =2.1× 10−6). These results provide evidence for a novel susceptibility gene for essential hypertension on chromosome 18q and show that it is possible to study the genetics of essential hypertension without stratifying by subphenotypes.","PeriodicalId":13233,"journal":{"name":"Hypertension: Journal of the American Heart Association","volume":"1 1","pages":"1044-1049"},"PeriodicalIF":0.0000,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"101","resultStr":"{\"title\":\"Linkage of Essential Hypertension to Chromosome 18q\",\"authors\":\"K. Kristjánsson, A. Manolescu, A. Kristinsson, T. Hardarson, H. Knudsen, Sigurdur Ingason, G. Thorleifsson, M. Frigge, A. Kong, J. Gulcher, K. Stefánsson\",\"doi\":\"10.1161/01.HYP.0000018580.24644.18\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We performed a genomewide scan with 904 microsatellite markers using 120 extended Icelandic families with 490 hypertensive patients. The families were identified by cross-matching a list of hypertensive patients from the Hypertension Clinic of the University Hospital (Landspitalinn) in Iceland with a genealogy database of the entire Icelandic nation. After adding 5 markers, we found linkage to chromosome 18q with an allele-sharing LOD score of 4.60 (P =2.1× 10−6). These results provide evidence for a novel susceptibility gene for essential hypertension on chromosome 18q and show that it is possible to study the genetics of essential hypertension without stratifying by subphenotypes.\",\"PeriodicalId\":13233,\"journal\":{\"name\":\"Hypertension: Journal of the American Heart Association\",\"volume\":\"1 1\",\"pages\":\"1044-1049\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"101\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hypertension: Journal of the American Heart Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1161/01.HYP.0000018580.24644.18\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hypertension: Journal of the American Heart Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1161/01.HYP.0000018580.24644.18","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Linkage of Essential Hypertension to Chromosome 18q
We performed a genomewide scan with 904 microsatellite markers using 120 extended Icelandic families with 490 hypertensive patients. The families were identified by cross-matching a list of hypertensive patients from the Hypertension Clinic of the University Hospital (Landspitalinn) in Iceland with a genealogy database of the entire Icelandic nation. After adding 5 markers, we found linkage to chromosome 18q with an allele-sharing LOD score of 4.60 (P =2.1× 10−6). These results provide evidence for a novel susceptibility gene for essential hypertension on chromosome 18q and show that it is possible to study the genetics of essential hypertension without stratifying by subphenotypes.
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