1273:发现一种有效的、选择性的、口服生物可利用的SOS1抑制剂rmmc -023，这是一种通过破坏RAS-SOS1相互作用来阻断RAS激活的体内化合物

{"title":"1273:发现一种有效的、选择性的、口服生物可利用的SOS1抑制剂rmmc -023，这是一种通过破坏RAS-SOS1相互作用来阻断RAS激活的体内化合物","authors":"A. Buckl, E. Quintana, Grace J. Lee, N. Shifrin, Mengqi Zhong, L. Garrenton, David C. Montgomery, Carlos Stahlhut, F. Zhao, D. Whalen, Severin Thompson, Arlyn Tambo-ong, Micah J. Gliedt, J. Knox, Cregg James Joseph, N. Aay, Jong Choi, Bao Nguyen, Atti Tripathi, Ruiping Zhao, Mae Saldajeno-Concar, Abby Marquez, Daphne Hsieh, Laura L. McDowell, E. Koltun, Alun Bermingham, D. Wildes, Mallika Singh, Zhengping Wang, R. Hansen, Jan Smith, A. Gill","doi":"10.1158/1538-7445.AM2021-1273","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":12258,"journal":{"name":"Experimental and Molecular Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Abstract 1273: Discovery of a potent, selective, and orally bioavailable SOS1 inhibitor, RMC-023, anin vivotool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction\",\"authors\":\"A. Buckl, E. Quintana, Grace J. Lee, N. Shifrin, Mengqi Zhong, L. Garrenton, David C. Montgomery, Carlos Stahlhut, F. Zhao, D. Whalen, Severin Thompson, Arlyn Tambo-ong, Micah J. Gliedt, J. Knox, Cregg James Joseph, N. Aay, Jong Choi, Bao Nguyen, Atti Tripathi, Ruiping Zhao, Mae Saldajeno-Concar, Abby Marquez, Daphne Hsieh, Laura L. McDowell, E. Koltun, Alun Bermingham, D. Wildes, Mallika Singh, Zhengping Wang, R. Hansen, Jan Smith, A. Gill\",\"doi\":\"10.1158/1538-7445.AM2021-1273\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":12258,\"journal\":{\"name\":\"Experimental and Molecular Therapeutics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental and Molecular Therapeutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1158/1538-7445.AM2021-1273\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental and Molecular Therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1158/1538-7445.AM2021-1273","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}