抗菌肽,治疗癌前病变痤疮的新方法综述

Diana M. Gómez, Y. Lone, Luz M. Salazar, J. Trojan.
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引用次数: 7

摘要

痤疮是最常见的上皮疾病之一,影响着世界上大约80%的年龄在16到35岁之间的人口。它是由多种因素引起的,如遗传易感性和激素改变,包括生长因子igf - 1等。痤疮与igf - 1表达有关,可能与恶性疾病的发生有关。痤疮的病理限于毛囊皮脂腺单位。这种进化是由细菌痤疮丙酸杆菌(P. acnes)定植的增加所控制的。痤疮在临床上表现为粉刺的出现,并有炎症倾向。最后会造成创伤,损害患者的自尊和生活质量。作为拟议的治疗方法,外部治疗已被开发,如igf - 1抑制剂等。作为一种内部治疗,研究了患者免疫系统对入侵微生物的先天反应,突出了抗微生物肽作为宿主自身防御分子的作用。这项工作显示了最相关的和当前的抗菌肽的汇编,这些抗菌肽可以用作潜在的治疗剂,用于对抗皮肤中与痤疮疾病相关的微生物。*通讯对象:哥伦比亚波哥大国立大学化学系理学院D.M. Gomez, E-mail: dimgomezmo@unal.edu.co哥伦比亚波哥大国立大学ICGT, Cll 128 b, Kr 18-11, J. Trojan, E-mail: genetherapy@hotmail.fr
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antimicrobial peptides, novel solution for the treatment of precancerous disease acne - A review
Acne is one of the most common epithelial diseases affecting approximately 80% of the world's population between the ages of 16 and 35. It is caused by multiple factors such as genetic predisposition and hormonal alteration including growth factor IGF-I, among others. Acne being related to IGF-I expression, is involved in possible apparition of malignant diseases. The pathology of acne is limited to the pilosebaceous unit. The evolution is governed by the increase in colonization of the bacteria Propionibacterium acnes (P. acnes). Acne is clinically manifested by the appearance of comedones with a tendency to inflammation. Finally causes scarring damaging self-esteem and quality of life of those who suffer it. As proposed therapies, external treatments have been developed such as inhibitors of IGF-I among others. As an internal treatment, the innate response of the patient's immune system to the presence of an invading microorganism has been studied, highlighting anti-microbial peptides as the host's own defense molecules. This work shows a compilation of the most relevant and current antimicrobial peptides that could be used as potential therapeutic agents against microorganisms located in the skin and related to acne disease. *Correspondence to: D.M. Gomez, Faculty of Sciences, Dept. Chemistry, Univ. Nacional, Bogotá D.C., Colombia, E-mail: dimgomezmo@unal.edu.co J. Trojan, ICGT, Cll 128 b, Kr 18-11, Bogotá D.C., Colombia, E-mail: genetherapy@hotmail.fr
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