头颈部皮肤鳞状细胞癌与基底细胞癌免疫细胞浸润的比较研究

IF 0.4 Q4 ONCOLOGY
Shirin Saravani, Hamideh Kadeh, Mahya Tavakoli Amin, Narges Ghavidel
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引用次数: 0

摘要

背景:肿瘤相关组织嗜酸性粒细胞和肥大细胞在肿瘤生物学行为中的作用尚不清楚。目的:本研究比较头颈部皮肤鳞状细胞癌(cSCC)和基底细胞癌(BCC)中嗜酸性粒细胞和肥大细胞计数,并评价其与临床病理因素的关系。方法:采用天狼星红和甲苯胺蓝染色技术分别对46例BCC和30例cSCC标本进行嗜酸性粒细胞和肥大细胞计数的组织病理切片进行描述性分析研究。数据分析采用Pearson相关、t检验、ANOVA检验。结果:BCC和cSCC的平均嗜酸性粒细胞计数分别为35.43±35和331.27±321.68 /10 HPF,差异有统计学意义(P = 0.001)。BCC和cSCC的肥大细胞浸润水平分别为55.33±39.90和63.67±40.86。然而,该变量在BCC和cSCC两组样本之间无显著差异(P = 0.380)。此外,3级cSCC的平均嗜酸性粒细胞和肥大细胞计数高于其他级别;然而,这种差异仅对肥大细胞有统计学意义。此外,cSCC和BCC的平均嗜酸性粒细胞/肥大细胞计数与年龄和性别无显著关系。结论:考虑到嗜酸性粒细胞在cSCC中比在BCC中存在更多,嗜酸性粒细胞可能是导致cSCC比BCC更具生物学和临床侵袭性行为的因素之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Study of Immune Cells Infiltration in Cutaneous Squamous Cell Carcinoma and Basal Cell Carcinoma of the Head and Neck
Background: The role of tumor-associated tissue eosinophils and mast cells in the biological behavior of tumors remains unclear. Objectives: This study was performed to compare the eosinophil and mast cell counts in the cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) of the head and neck and to evaluate their relationship with clinicopathologic factors. Methods: The current descriptive-analytical study was conducted on the histopathologic slides of 46 BCC and 30 cSCC samples prepared by using Sirius red and toluidine blue staining techniques for eosinophil and mast cell counts, respectively. The data were analyzed, using Pearson’s correlation, t test, and ANOVA test. Results: The BCC and cSCC samples had mean eosinophil counts of 35.43 ± 35 and 331.27 ± 321.68 eosinophil/10 HPF, respectively, and this difference was statistically significant (P = 0.001). The levels of the mast cell infiltration were obtained as 55.33 ± 39.90 and 63.67 ± 40.86 in BCC and cSCC, respectively. However, this variable was not significantly different between the two groups of BCC and cSCC samples (P = 0.380). In addition, the mean eosinophil and mast cell counts were higher in cSCC grade 3 than in other grades; however, this difference was statistically significant only for the mast cells. Furthermore, the mean eosinophil/mast cell count in cSCC and BCC showed no significant relationship with age and gender. Conclusions: Considering the greater presence of eosinophils in cSCC than in BCC, eosinophils may be concluded to be among the factors responsible for more biologically and clinically invasive behaviors of cSCC, compared to those of BCC.
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
67
期刊介绍: International Journal of Cancer Management (IJCM) publishes peer-reviewed original studies and reviews on cancer etiology, epidemiology and risk factors, novel approach to cancer management including prevention, diagnosis, surgery, radiotherapy, medical oncology, and issues regarding cancer survivorship and palliative care. The scope spans the spectrum of cancer research from the laboratory to the clinic, with special emphasis on translational cancer research that bridge the laboratory and clinic. We also consider original case reports that expand clinical cancer knowledge and convey important best practice messages.
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