{"title":"全氟烷基的亲核加成","authors":"P. Beier, M. Zibinsky, G. Prakash","doi":"10.1002/0471264180.OR091.01","DOIUrl":null,"url":null,"abstract":"The trifluoromethyl and perfluoroalkyl functional groups possess significant thermal, chemical, and metabolic stability, as well as high lipophilicity and electronegativity. These physicochemical properties render fluorinated carbon residues indispensable in diverse applications, such as agrochemistry, drug design, and material chemistry. The generation and properties of nucleophilic perfluoroalkyl reagents as well as the scope and limitations of their additions to various electrophilic partners is described in this chapter. \n \n \nKeywords: \n \nfluorine; \ntrifluoromethyl; \nperfluoroalkyl; \nnucleophilic addition","PeriodicalId":19539,"journal":{"name":"Organic Reactions","volume":"61 1","pages":"1-492"},"PeriodicalIF":0.0000,"publicationDate":"2016-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Nucleophilic Additions of Perfluoroalkyl Groups\",\"authors\":\"P. Beier, M. Zibinsky, G. Prakash\",\"doi\":\"10.1002/0471264180.OR091.01\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The trifluoromethyl and perfluoroalkyl functional groups possess significant thermal, chemical, and metabolic stability, as well as high lipophilicity and electronegativity. These physicochemical properties render fluorinated carbon residues indispensable in diverse applications, such as agrochemistry, drug design, and material chemistry. The generation and properties of nucleophilic perfluoroalkyl reagents as well as the scope and limitations of their additions to various electrophilic partners is described in this chapter. \\n \\n \\nKeywords: \\n \\nfluorine; \\ntrifluoromethyl; \\nperfluoroalkyl; \\nnucleophilic addition\",\"PeriodicalId\":19539,\"journal\":{\"name\":\"Organic Reactions\",\"volume\":\"61 1\",\"pages\":\"1-492\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-12-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Reactions\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/0471264180.OR091.01\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Reactions","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/0471264180.OR091.01","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The trifluoromethyl and perfluoroalkyl functional groups possess significant thermal, chemical, and metabolic stability, as well as high lipophilicity and electronegativity. These physicochemical properties render fluorinated carbon residues indispensable in diverse applications, such as agrochemistry, drug design, and material chemistry. The generation and properties of nucleophilic perfluoroalkyl reagents as well as the scope and limitations of their additions to various electrophilic partners is described in this chapter.
Keywords:
fluorine;
trifluoromethyl;
perfluoroalkyl;
nucleophilic addition
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