不寻常的毛细胞白血病病例与不寻常的免疫表型:诊断的挑战

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AJSP-Reviews and Reports Pub Date : 2019-11-01 DOI:10.1097/PCR.0000000000000338

Ying Liu, Elham Vali-Betts, N. Ku

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摘要

毛细胞白血病(HCL)是一种罕见的惰性b细胞肿瘤，具有独特的形态和免疫表型特征。免疫表型上，HCL中的肿瘤细胞对b细胞标记物如CD19、CD20和CD22强烈阳性。它们也特征性地表达CD11c、CD25、CD103和CD123，但缺乏CD5、CD10和CD23。不常见的HCL免疫表型会给诊断带来挑战。在这里，我们报告2例罕见的cd5阳性和cd10阳性HCL。

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Unusual Cases of Hairy Cell Leukemia With Uncommon Immunophenotypes: A Diagnostic Challenge

Hairy cell leukemia (HCL) is a rare indolent B-cell neoplasmwith distinct morphologic and immunophenotypic features. Immunophenotypically, the neoplastic cells in HCL are strongly positive for B-cell markers, such as CD19, CD20, and CD22. They also characteristically express CD11c, CD25, CD103, and CD123, but lack CD5, CD10, and CD23. Uncommon immunophenotypes of HCL can pose diagnostic challenges. Here, we report 2 unusual cases of CD5-positive and CD10-positive HCL.

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来源期刊

AJSP-Reviews and Reports PATHOLOGY-

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期刊介绍： Each issue of Pathology Case Reviews examines one vital theme in the field with peer-reviewed, clinically oriented case reports that focus on diagnosis, specimen handling and reports generation. Each theme-oriented issue covers both histopathologic and cytopathologic cases, offering a comprehensive perspective that includes editorials and review articles of the newest developments in the field, differential diagnosis hints, applications of new technologies, reviews of current issues and techniques and an emphasis on new approaches.