Synthesis and Antibacterial Activity of N-(un)substituted-N- ((3,4-Methylenedioxyphenyl)methyl)arylsulfonamides

Sulfonamides belong to an active group with biological activities and these activities can be enhanced by introducing heterocyclic moiety. N-((3,4-methylenedioxyphenyl)methyl) arylsulfonamides (3a-f) were synthesized by gearing up (3,4methylenedioxyphenyl)methyl amine (1) and arylsulfonyl chlorides (2a-f) in a weak basic aqueous medium. The target molecules, 6a-f and 7a-f were yielded by the reaction of 3a-f with ethyl iodide (4) and 4-flourobenzyl chloride (5) respectively in a weak basic aprotic polar medium. Structural analysis of the synthesized molecules was processed through the spectral data of IR, 1 HNMR, 13 C-NMR and EIMS. All the synthesized molecules were evaluated for the antibacterial activity and remained moderately