尼日利亚2型糖尿病患者胰岛素抵抗的替代标志物和预测因素:一项横断面研究

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
I. Odeniyi, Ukamaka Odife, O. Fasanmade, A. Ohwovoriole
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引用次数: 1

摘要

背景:本研究旨在识别和比较男性和女性胰岛素抵抗(IR)的替代标记物,并比较使用不同替代标记物的IR患病率。方法:本研究是一项以医院为基础的分析性横断面研究,研究对象为尼日利亚2型糖尿病(T2DM)患者。共有234人(131名2型糖尿病患者和103名健康人)被邀请参加这项研究。199人完成了这项研究。测量身高[m]、体重[kg]、腰围[cm]、臀围[cm]。IR评分(IRS)采用空腹基础胰岛素、空腹c肽、葡萄糖-胰岛素比值、定量胰岛素敏感性检查指数、稳态模型评估(HOMA-IR)、homa -c肽6项指标。结果:以IR >11为诊断标准,T2DM患者有52例(41.6%),对照组有21例(28.4%)。45%的女性糖尿病患者和36.4%的男性糖尿病患者分别患有IR,而对照组女性的31.8%和对照组男性的23.3%分别患有IR。内脏脂肪指数(VAI)预测值最佳,受试者工作特征曲线下面积最大(0.648)。结论:IR在女性中的患病率不明显高于男性。VAI是预测男性研究参与者是否存在IR的最佳替代指标,而腰围是预测女性研究参与者是否存在IR的最佳替代指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Surrogate markers and predictors of insulin resistance in Nigeria patients with Type 2 diabetes mellitus: A cross sectional study
Background: This study set out to identify and compare surrogate markers of insulin resistance (IR) in males and females and compare the prevalence of IR using different surrogate markers. Methods: The study was an analytical cross-sectional hospital-based study among Nigerians with Type 2 diabetes mellitus (T2DM). A total of 234 (131 T2DM and 103 healthy) persons were invited to participate in the study. One hundred and ninety-nine persons completed the study. The following anthropometric measurements were taken (height [m], weight [kg], waist circumference [cm], and hip circumference [cm]). IR score (IRS) was derived using these six measurements: fasting basal insulin, fasting C-peptide, glucose-insulin ratio, quantitative insulin sensitivity check index, homeostasis model assessment (HOMA-IR), HOMA-c-peptide. Results: Using an IRS of >11 as criteria for IR, 52 (41.6%) of T2DM, and 21 (28.4%) of the control group were found to have IR. Forty-five percent of the DM females and 36.4% of DM males had IR, respectively, whereas 31.8% of the control females and 23.3% of control males had IR, respectively. Visceral Adiposity Index (VAI) had the best predictive value with the highest area under the receiver operating characteristic curve (0.648). Conclusion: The prevalence of IR is nonsignificantly higher in females than males. VAI is the best surrogate marker to predict the presence of IR among the male study participants, while waist circumference is the best surrogate marker to predict the presence of IR among the female study participants.
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来源期刊
Journal of Clinical Sciences
Journal of Clinical Sciences MEDICINE, GENERAL & INTERNAL-
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审稿时长
45 weeks
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