{"title":"文拉法辛-普罗帕酮相互作用所致器质性精神病","authors":"F. Pfeffer, M. Grube","doi":"10.2190/8HJA-LPRY-P16X-BH8U","DOIUrl":null,"url":null,"abstract":"Objective: An extraordinary case of an organic psychosis during the treatment of a patient with a bipolar affective disorder. Methods: Clinical observation and further investigations including monitoring of serum levels (case report). Results: A significant interaction between venlafaxine and propafenone causes markedly increased serum levels of venlafaxine correlating with unexpected psychopathological changes. Conclusions: There is a potentially dangerous interaction between venlafaxine and propafenone. Serum levels of venlafaxine should be monitored if propafenone is added.","PeriodicalId":22510,"journal":{"name":"The International Journal of Psychiatry in Medicine","volume":"7 1","pages":"427 - 432"},"PeriodicalIF":0.0000,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"17","resultStr":"{\"title\":\"An Organic Psychosis Due to a Venlafaxine-Propafenone Interaction\",\"authors\":\"F. Pfeffer, M. Grube\",\"doi\":\"10.2190/8HJA-LPRY-P16X-BH8U\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: An extraordinary case of an organic psychosis during the treatment of a patient with a bipolar affective disorder. Methods: Clinical observation and further investigations including monitoring of serum levels (case report). Results: A significant interaction between venlafaxine and propafenone causes markedly increased serum levels of venlafaxine correlating with unexpected psychopathological changes. Conclusions: There is a potentially dangerous interaction between venlafaxine and propafenone. Serum levels of venlafaxine should be monitored if propafenone is added.\",\"PeriodicalId\":22510,\"journal\":{\"name\":\"The International Journal of Psychiatry in Medicine\",\"volume\":\"7 1\",\"pages\":\"427 - 432\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The International Journal of Psychiatry in Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2190/8HJA-LPRY-P16X-BH8U\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The International Journal of Psychiatry in Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2190/8HJA-LPRY-P16X-BH8U","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
An Organic Psychosis Due to a Venlafaxine-Propafenone Interaction
Objective: An extraordinary case of an organic psychosis during the treatment of a patient with a bipolar affective disorder. Methods: Clinical observation and further investigations including monitoring of serum levels (case report). Results: A significant interaction between venlafaxine and propafenone causes markedly increased serum levels of venlafaxine correlating with unexpected psychopathological changes. Conclusions: There is a potentially dangerous interaction between venlafaxine and propafenone. Serum levels of venlafaxine should be monitored if propafenone is added.
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