在农村初级保健中心预防药物相互作用及其相关因素的临床药物相互作用警报系统

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL

Bangladesh Journal of Medical Science Pub Date : 2023-06-16 DOI:10.3329/bjms.v22i3.66962

Flori R. Sari, S. Anwar, -. Risahmawati, Marita Fadhilah, Fika Ekayanti

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引用次数: 0

摘要

目的:药物-药物相互作用(DDI)发生在处方超过一种药物后。印度尼西亚国家初级保健中的DDI及其相关因素尚未报道。材料和方法:通过这项描述性横断面研究，我们使用基于临床的药物相互作用警报(CIDIA)警报系统分析了DDI的发病率。通过分析来自9个初级卫生保健机构的处方(n=2410)进行了目的性研究。结果:CIDIA预警系统在所有处方中检出DDI发生率为7.5%，分为轻度(63%)、中度(36%)和重度(1%)。DDI在女性患者、18岁以上患者和服用3种及以上药物患者中的发生率均有统计学意义(p<0.01)。各类别DDI发生率最高的是扑热息痛-多潘立酮;地塞米松-甲氧胺酸和卡托普利-别嘌呤醇。结论:CIDIA报警系统可为检测DDI提供有益的支持。在预防DDI发生率方面，应特别仔细考虑女性患者、老年患者和接受三种或三种以上药物治疗的患者。《孟加拉国医学科学杂志》第22卷第23年7月3日第667-675页

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A Clinical-Based Drug Interaction Alert (CIDIA) System for Preventing Drug Interaction and Its Associated Factors at Rural Primary Care Centres

Objectives: Drug-drug interaction (DDI) occurs following the prescription of more than one drug. DDI and its associated factors in Indonesia’s country’s primary care have not been reported. Materials and Methods: Through this descriptive cross-sectional study, we analysed the DDI incidence using the Clinical-Based Drug Interaction Alert (CIDIA) alert system. Purposive research was carried out by analysing prescriptions (n=2410) from nine primary health cares. Results: CIDIA alert system detected 7.5% DDI incidence in all prescriptions, categorized as mild (63%), moderate (36%) and serious (1%). Significant DDI incidence was observed in female patients (p<0.01), in patients older than 18 years (p<0.01) and in patients receiving three or more drugs (p<0.01). The most frequent incidence of DDI from each category was paracetamol-domperidone; dexamethasone-mefenamic acid and captopril-allopurinol. Conclusion: CIDIA alert system has been shown to provide beneficial support in detecting DDI incidence. Careful consideration should be addressed particularly towards female patients, older patients, and patients receiving three or more drugs in preventing DDI incidence. Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 667-675

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