Uncommon Events of Fall and Mood Changes Observed in Post-COVID-19 Patients: A Case Series

Abstract Coronavirus disease 2019 (COVID-19) infection in some patients has been documented to cause acute central nervous system (CNS) affection, or CNS depression, even in the absence of demonstrable hypoxia. These observations indicate that there may be some direct effect of the virus on CNS. In this case series of cured post-COVID-19 cases, mood changes like elation, depression, and emotionally labile state have been reported in three previously healthy individuals. The mood changes are waning very slowly in them with the passage of time. All of them also sustained fall sometime following acute COVID-19. Fall is considered to be an event indicating frailty and old age, and there is no mood change associated with fall in that population. Here, the three cases are being reported because neither fall nor mood changes during post-COVID-19 phase have been reported as yet to the best of our knowledge. The case series is worth reporting to generate awareness about the matter in the scientific community and also to indicate that further research in this field is required either to accept or to reject any correlation between COVID-19 infection and fall or mood change in otherwise healthy individuals, which can even be due to some direct effect of the virus on CNS.