E. Yuanita, Baiq Khaeratul Jannah, M. Ulfa, Sudirman, Baiq Nila Sari Ningsih, N. K. T. Dharmayani
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C-prenylation of 1,3 dihydroxyxanthone: synthesis, characterization and antibacterial activity
Prenylated 1,3-dihydroxyxanthone has been successfully synthesized using Prenyl bromide and KOH. Characterization of the synthesized compound using Infra Red (IR) and Nuclear Magnetic Resonance (1H-NMR) showed that monosubstituted c-prenylation was occurred at carbon number 2 to form 1,3-dihydroxy-2-prenylxanthone. The synthesis result was a yellow-brown paste with a yield of 43.09%. This prenylated 1,3-dihydroxyxanthone had moderate antibacterial activity against Escherichia coli with an inhibition zone > 5 mm at a concentration of 15%.
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