系统性炎性体生物标志物作为糖尿病视网膜病变进展的预测因子:来自一项初步研究的证据

C. Kuo, I. Rupenthal, Michael Booth, Rinki Murphy, Odunayo O. Mugisho
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引用次数: 0

摘要

核苷酸结合寡聚化结构域(NOD)样受体(NLR)蛋白3 (NLRP3)炎症小体途径被认为介导糖尿病视网膜病变(DR)的慢性炎症;然而,其对DR进展的影响仍有待阐明。因此,本初步研究的主要目的是确定全身性炎性体生物标志物白介素(IL)-1β和IL-18是否可用于预测DR的进展。将DR筛查结果与2型糖尿病患者在基线和减肥手术后1年的体重、糖化血红蛋白(HbA1c)水平、血浆炎症小体生物标志物(IL-1β和IL-18)水平以及一般炎症标志物(c -反应蛋白(CRP)、IL-6、IL-8、肿瘤坏死因子α (TNF-α)和血管内皮生长因子(VEGF))进行分析。横断面分析显示体重、HbA1c、CRP和IL-18与DR严重程度无关。进展组与稳定组和进展组相比,IL-18和CRP水平的相对变化更高。此外,血浆CRP水平的相对变化与IL-18水平相关。虽然需要更大的队列进一步验证,但该初步研究支持全身性炎性体激活与DR进展相关的假设。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Systemic Inflammasome Biomarkers as Predictors of Diabetic Retinopathy Progression: Evidence from a Pilot Study
The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) protein 3 (NLRP3) inflammasome pathway is believed to mediate chronic inflammation in diabetic retinopathy (DR); however, its impact on the progression of DR remains to be elucidated. Therefore, the primary aim of this pilot study was to determine whether systemic inflammasome biomarkers interleukin (IL)-1β and IL-18 can be used to predict DR progression. DR screening results were analyzed against weight, level of glycated hemoglobin (HbA1c), and plasma levels of inflammasome biomarkers (IL-1β and IL-18), as well as general inflammation markers (C-reactive protein (CRP), IL-6, IL-8, tumor necrosis factor-alpha (TNF-α), and vascular endothelial growth factor (VEGF)) in patients with type 2 diabetes at baseline and 1 year post-bariatric surgery. Cross-sectional analysis demonstrated that weight, HbA1c, CRP, and IL-18 did not correlate with DR severity. The progressed group showed a higher relative change in IL-18 and CRP levels compared to the stable and regressed groups. Furthermore, relative changes in plasma CRP levels correlated with those of IL-18. Although further validation with larger cohorts is necessary, this pilot study supports the hypothesis that systemic inflammasome activation is associated with DR progression.
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