Basal cell carcinoma – Pathology

Basal cell carcinoma (BCC) that originates from the basal cells of the interfollicular epidermis and/or hair follicle is a locally aggressive neoplasm. The mutations that activate the hedgehog signaling pathway play an important pathogenic role. BCC can also occur in conjunction with familial cancer syndromes. A better understanding of the intricate molecular pathogenesis has opened up therapeutic options that are found useful in patients with aggressive or metastatic BCC. Apart from the morphological features, histopathology is crucial in assessing the prognosis of BCC and deciding the best treatment option.