神经退行性疾病中的内质网应激:从发病机制到治疗干预

IF 0.7
Felipe Cabral-Miranda, C. Hetz
{"title":"神经退行性疾病中的内质网应激:从发病机制到治疗干预","authors":"Felipe Cabral-Miranda, C. Hetz","doi":"10.1515/ersc-2017-0002","DOIUrl":null,"url":null,"abstract":"Abstract The conception that protein aggregates composed by misfolded proteins underlies the occurrence of several neurodegenerative diseases suggests that this phenomenon may have a common origin, ultimately driven by disruption of proteostasis control. The unfolded protein response (UPR) embodies a major element of the proteostasis network, which is engaged by endoplasmic reticulum (ER) stress. Chronic ER stress may operate as a possible mechanism of neurodegeneration, contributing to synaptic alterations, neuroinflammation and neuronal loss. In this review we discuss most recent findings relating ER stress and the development of distinct neurodegenerative diseases, and the possible strategies for disease intervention.","PeriodicalId":29730,"journal":{"name":"Cell Pathology","volume":"58 1","pages":"11 - 26"},"PeriodicalIF":0.7000,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"ER stress in neurodegenerative disease: from disease mechanisms to therapeutic interventions\",\"authors\":\"Felipe Cabral-Miranda, C. Hetz\",\"doi\":\"10.1515/ersc-2017-0002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract The conception that protein aggregates composed by misfolded proteins underlies the occurrence of several neurodegenerative diseases suggests that this phenomenon may have a common origin, ultimately driven by disruption of proteostasis control. The unfolded protein response (UPR) embodies a major element of the proteostasis network, which is engaged by endoplasmic reticulum (ER) stress. Chronic ER stress may operate as a possible mechanism of neurodegeneration, contributing to synaptic alterations, neuroinflammation and neuronal loss. In this review we discuss most recent findings relating ER stress and the development of distinct neurodegenerative diseases, and the possible strategies for disease intervention.\",\"PeriodicalId\":29730,\"journal\":{\"name\":\"Cell Pathology\",\"volume\":\"58 1\",\"pages\":\"11 - 26\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2017-04-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell Pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1515/ersc-2017-0002\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/ersc-2017-0002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8

摘要

由错误折叠的蛋白质组成的蛋白质聚集体是几种神经退行性疾病发生的基础,这一概念表明这种现象可能有一个共同的起源,最终是由蛋白质平衡控制的破坏所驱动的。未折叠蛋白反应(UPR)是蛋白质静止网络的一个重要组成部分,该网络由内质网(ER)应激参与。慢性内质网应激可能是神经变性的一种可能机制,有助于突触改变、神经炎症和神经元丢失。在这篇综述中,我们讨论了内质网应激与不同神经退行性疾病发展的最新发现,以及可能的疾病干预策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ER stress in neurodegenerative disease: from disease mechanisms to therapeutic interventions
Abstract The conception that protein aggregates composed by misfolded proteins underlies the occurrence of several neurodegenerative diseases suggests that this phenomenon may have a common origin, ultimately driven by disruption of proteostasis control. The unfolded protein response (UPR) embodies a major element of the proteostasis network, which is engaged by endoplasmic reticulum (ER) stress. Chronic ER stress may operate as a possible mechanism of neurodegeneration, contributing to synaptic alterations, neuroinflammation and neuronal loss. In this review we discuss most recent findings relating ER stress and the development of distinct neurodegenerative diseases, and the possible strategies for disease intervention.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信