结核患者外周血25-羟基维生素D表达与免疫细胞亚群的相关性

中国热带医学 Pub Date : 2020-11-01 DOI:10.13604/J.CNKI.46-1064/R.2020.11.07

Zhai Yunxia, Xu Ping, Z. Jing, Xu Junchi, Song Huafeng

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引用次数: 0

摘要

目的探讨血清25-羟基维生素D与结核病患者的关系，分析其与机体免疫细胞的关系，为结核病的防治提供新的思路。方法以2018年12月至2019年5月苏州市第五人民医院收治的54例确诊结核病患者为实验组，同期在我院门诊体检的健康人群60例为对照组。比较两组25-羟基维生素D水平，发现25-羟基维生素D与结核病的关系。采用Spearman相关性分析25-羟基维生素D与结核病患者CD3 +、CD4 +、CD8 +、CD4 + /CD8 +比值及其他免疫细胞水平的相关性。结果结核患者血清25-羟基维生素D水平为9.75 (5.1,15.8)ng / mL，显著低于健康人群的16.8 (6.8,32.7)ng / mL (P < 0.05)。血清人体内25 -羟维生素D水平与外周血CD4 +级别呈极显著的正相关关系,和CD4 + / CD8 +比值(r = 0.317 - 2和0.404 - 4 P 0.05),且血清25 -羟基维生素D水平与外周血CD4 +、CD4 + / CD8 +呈明显正相关(r = 0.317 - 2、0.404 - 4,均P < 0.05),与外周血CD8 +呈明显负相关(r = -0.329, P = 0.015);与NK细胞水平呈正相关(r = 0.326, P = 0.016),与B淋巴细胞及单核细胞呈负相关(r = -0.333, -0.301,均P < 0.05)。“”“”“”“”“”“”“”“”“”-羟

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Correlation of expression of 25-hydroxyvitamin D in peripheral blood and immune cell subsets of tuberculosis patients

Objective This study aim to discover the relationship between serum 25-hydroxyvitamin D and tuberculosis patients, and we achieve new ideas for the prevention and treatment of tuberculosis by analyzed its correlation with body immunity cells. Methods Fifty-four patients diagnosed with tuberculosis who admitted to Suzhou Fifth People’s Hospital from December 2018 to May 2019 were included in the experimental group, and 60 healthy persons undergoing outpatient medical examinations in our hospital at the same period were selected as the control group. 25-hydroxyvitamin D levels were compared in two groups for discovering the relationship between 25-hydroxyvitamin D and tuberculosis. Spearman correlation was used to analyze the correlation of 25-hydroxyvitamin D with these levels of CD3 + , CD4 + , CD8 + and CD4 + /CD8 + ratio as well as other immune cells in patients with tuberculosis. Results The serum 25-hydroxyvitamin D level of TB patients 9.75 (5.1, 15.8) ng / mL was significantly lower than that of healthy persons 16.8 (6.8, 32.7) ng / mL ( P 0.05).The serum 25-hydroxyvitamin D level was significantly positively correlated with peripheral blood CD4 + level and CD4 + /CD8 + ratio ( r =0.317 2 and 0.404 4, both P 0.05) , 且血清 25-羟基维生素 D 水平与外周血 CD4 + 、CD4 + /CD8 + 呈明显正相关 ( r =0.317 2、0.404 4, 均 P <0.05) , 与外周血 CD8 + 呈明显负相关 ( r =-0.329 9, P =0.015) ; 与 NK 细胞水平呈正相关 ( r =0.326 2, P =0.016), 与 B 淋巴细胞及单核细胞呈负相关 ( r =-0.333 9、-0.301 2, 均 P <0.05)。结论结核患者中血清 25-羟基维生素 D 明显降低, 可能参与了机体免疫功能调节。

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来源期刊

中国热带医学

CiteScore

0.60

自引率

0.00%

发文量

13927

期刊介绍： China Tropical Medicine, was approved by the Ministry of Science and Technology in 2001, is the only tropical medicine periodical under the charge of the National Health Commission of China. It’s organized by Hainan Provincial Center for Disease Prevention and Control, and Chinese Preventive Medicine Association. The journal is indexed by the following database: Scopus database, Embase database, EBSCO Database, The Western Pacific Region index medicus (WPRIM), American Chemical Abstracts (CA), International Centre for Agricultural and Biological Sciences Research Database (CABI), Global Health Database, Database of the Ulrich's Periodicals Directory, China Science and Technology Core Journals, China Core Journals (Selection) Database, Database of Chinese Biomedical Literature, Comprehensive Evaluation Database of Chinese Academic Journals, CAJCD Code of Conduct Excellent Journal, Database of Chinese SCI-Tech Periodicals, China Journal Full Text Database.