大鼠钙调节亲环蛋白配体的克隆

Sung Joong Lee, Kathryn Drabik, E. Benveniste
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引用次数: 5

摘要

对大鼠钙调节亲环蛋白配体(CAML) cDNA进行了克隆和测序。它预计有294个氨基酸的开放阅读框。CAML基因在整个物种中高度保守,其氨基酸序列分别与人类、小鼠和鸡的85、89和69%相同。星形胶质细胞、小胶质细胞和神经元的基因表达数据显示,CAML mRNA和蛋白在中枢神经系统的这些细胞类型中组成性表达。大鼠CAML的克隆将有助于进一步研究其功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cloning of Rat Calcium-Modulating Cyclophilin Ligand
Rat calcium-modulating cyclophilin ligand (CAML) cDNA was cloned and sequenced. It has a predicted open reading frame of 294 amino acids. The CAML gene is highly conserved throughout species, showing 85, 89 and 69% amino acid sequence identity to the human, mouse, and chicken genes, respectively. Gene expression data using astrocytes, microglia and neurons show that CAML mRNA and protein is constitu-tively expressed in these cell types of the central nervous system. The cloning of rat CAML will facilitate further investigations on the function of this molecule.
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