Mathematical and Computer Modeling as a Novel Approach for the Accelerated Development of New Inhalation and Intranasal Drug Delivery Systems

This paper presents modern methods of mathematical modeling, which are widely used in the development of new inhalation and intranasal drugs, including those necessary for the treatment of socially significant diseases, which include: tuberculosis, bronchial asthma, and mental and behavioral disorders. Based on the conducted studies, it was revealed that the methods of mathematical modeling used in the development of drugs are fragmented, and there is no single approach that would combine the existing methods. The results presented in the work should contribute to the development of a unified multiscale model as a new approach in mathematical modeling that contributes to the accelerated development and introduction to the market of new drugs with high bioavailability and the required therapeutic efficacy.