Mohamed Salah El-Din Ayoub , Marwa Mokbel El-Shafei , Wael Yousef Elias , Hala Ahmed El-kammar
{"title":"人唾液腺黏液表皮样癌CD44表达的免疫组织化学评价","authors":"Mohamed Salah El-Din Ayoub , Marwa Mokbel El-Shafei , Wael Yousef Elias , Hala Ahmed El-kammar","doi":"10.1016/j.fdj.2018.08.004","DOIUrl":null,"url":null,"abstract":"<div><p>CD44 is a cell adhesion molecule that functions in cell proliferation, differentiation, migration and angiogenesis, as well as in signaling for cell survival. CD44 acts also as the main hyaluronan receptor. CD44 has been implicated to have a role in carcinogenesis.</p></div><div><h3>Aim of the study</h3><p>In this study the expression of CD44 in mucoepidermoid carcinoma was detected and correlated with the histopathological grade.</p></div><div><h3>Material and methods</h3><p>peroxidase-antiperoxidase immunohistochemical technique for the detection of CD44 expression in mucoepidermoid carcinoma.</p></div><div><h3>Results</h3><p>There was no statistically significant difference between the expression of CD44 in high and low grade mucoepidermoid carcinoma. Yet, the pattern of expression varied in both.</p></div><div><h3>Conclusion</h3><p>CD44 pattern of expression correlates with mucoepidermoid carcinoma histopathological grade. Correlates with increased proliferative activity and presumably increased cellular motility.</p></div><div><h3>Summary</h3><p>From this study it was deducted that over-expression of CD44 correlates with increased proliferative activity and presumably increased cellular motility.</p></div>","PeriodicalId":100562,"journal":{"name":"Future Dental Journal","volume":"4 2","pages":"Pages 197-204"},"PeriodicalIF":0.0000,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.fdj.2018.08.004","citationCount":"3","resultStr":"{\"title\":\"Immunohistochemical evaluation of CD44 expression in mucoepidermoid carcinoma of human salivary glands\",\"authors\":\"Mohamed Salah El-Din Ayoub , Marwa Mokbel El-Shafei , Wael Yousef Elias , Hala Ahmed El-kammar\",\"doi\":\"10.1016/j.fdj.2018.08.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>CD44 is a cell adhesion molecule that functions in cell proliferation, differentiation, migration and angiogenesis, as well as in signaling for cell survival. CD44 acts also as the main hyaluronan receptor. CD44 has been implicated to have a role in carcinogenesis.</p></div><div><h3>Aim of the study</h3><p>In this study the expression of CD44 in mucoepidermoid carcinoma was detected and correlated with the histopathological grade.</p></div><div><h3>Material and methods</h3><p>peroxidase-antiperoxidase immunohistochemical technique for the detection of CD44 expression in mucoepidermoid carcinoma.</p></div><div><h3>Results</h3><p>There was no statistically significant difference between the expression of CD44 in high and low grade mucoepidermoid carcinoma. Yet, the pattern of expression varied in both.</p></div><div><h3>Conclusion</h3><p>CD44 pattern of expression correlates with mucoepidermoid carcinoma histopathological grade. Correlates with increased proliferative activity and presumably increased cellular motility.</p></div><div><h3>Summary</h3><p>From this study it was deducted that over-expression of CD44 correlates with increased proliferative activity and presumably increased cellular motility.</p></div>\",\"PeriodicalId\":100562,\"journal\":{\"name\":\"Future Dental Journal\",\"volume\":\"4 2\",\"pages\":\"Pages 197-204\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.fdj.2018.08.004\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Future Dental Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2314718018300685\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future Dental Journal","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2314718018300685","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Immunohistochemical evaluation of CD44 expression in mucoepidermoid carcinoma of human salivary glands
CD44 is a cell adhesion molecule that functions in cell proliferation, differentiation, migration and angiogenesis, as well as in signaling for cell survival. CD44 acts also as the main hyaluronan receptor. CD44 has been implicated to have a role in carcinogenesis.
Aim of the study
In this study the expression of CD44 in mucoepidermoid carcinoma was detected and correlated with the histopathological grade.
Material and methods
peroxidase-antiperoxidase immunohistochemical technique for the detection of CD44 expression in mucoepidermoid carcinoma.
Results
There was no statistically significant difference between the expression of CD44 in high and low grade mucoepidermoid carcinoma. Yet, the pattern of expression varied in both.
Conclusion
CD44 pattern of expression correlates with mucoepidermoid carcinoma histopathological grade. Correlates with increased proliferative activity and presumably increased cellular motility.
Summary
From this study it was deducted that over-expression of CD44 correlates with increased proliferative activity and presumably increased cellular motility.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
