表没食子儿茶素-3-没食子酸酯对脂肪细胞葡萄糖转运、分化及异常脂质代谢相关基因表达的影响

IF 1.2 4区农林科学 Q2 AGRICULTURE, MULTIDISCIPLINARY

Journal of Agricultural Science and Technology Pub Date : 2015-11-01 DOI:10.29335/tals.2015.51.25

Hyuck Choi, K. Myung

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引用次数: 0

摘要

背景:绿茶儿茶素已被证明可以促进身体脂肪的减少，并通过诱导细胞凋亡来抑制多种癌细胞的生长。目的:目的是确定表没食子儿茶素-3-没食子酸酯(EGCG)是否能够减少3T3-L1脂肪细胞的分化，并改变HepG2肝细胞中异常脂质代谢相关基因的表达。结果:EGCG抑制脂肪细胞分化相关基因的表达可能与阻滞3T3-L1细胞的葡萄糖摄取有关。EGCG降低了HepG2细胞中的胆固醇浓度，导致apoB 100的抑制程度相似，LDL受体和HMG-CoA还原酶mRNA水平升高。结论:EGCG可直接抑制3T3-L1脂肪细胞的分化，降低HepG2肝细胞脂质代谢相关基因的异常，可能是治疗肥胖和代谢的有效辅助药物

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The Effects of Epigallocatechin-3-gallate on Adipocyte Glucose Transport and Differentiation, and Aberrant Lipid Metabolism-related Genes Expression

Background: Green tea catechins have been shown to promote loss of body fat and to inhibit growth of many cancer cell types by inducing apoptosis. Objective: The objective was to determine if epigallocatechin-3-gallate (EGCG) has ability to reduce differentiation in 3T3-L1 adipocytes and alter expression of aberrant lipid metabolism-related genes in HepG2 hepatocytes. Results: EGCG attenuated differentiation related gene expressions of adipocytes likely due to retarding glucose uptake in 3T3-L1 cells. EGCG decreased the concentration of cholesterol in HepG2 cell, resulting in the similar degree of suppression in apoB 100, and of enhancement in LDL receptor and HMG-CoA reductase mRNA levels. Conclusion: These results demonstrated that EGCG can act directly to inhibit differentiation of 3T3-L1 adipocytes and reduce abnormality in lipid metabolism-related genes in HepG2 hepatocytes, thus, could be a potent adjuvant in the treatment of obesity and metabolism

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来源期刊

Journal of Agricultural Science and Technology AGRICULTURE, MULTIDISCIPLINARY-

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

4.5 months

期刊介绍： Journal of Agricultural Science and Technology is one of the TMU Press journals that is published by the responsibility of its Editor-in-Chief and Editorial Board in the determined scopes. Journal of Agricultural Science and Technology (JAST) is an international research journal published bimonthly for the purpose of advancing the scientific studies. The subjects covered by JAST include all aspects of agriculture and natural resources (see Areas Covered). The journal will consider submissions from all over the world, on research works not being published or submitted for publication towards publication as full paper, review article and research note. The Papers are published in English with an extra abstract in Persian.