新的具有抗病毒和抗癌活性的4-亚胺酰脲胺衍生物

Y. Kornii, O. Shablykin, O. Shablykina, V. Brovarets
{"title":"新的具有抗病毒和抗癌活性的4-亚胺酰脲胺衍生物","authors":"Y. Kornii, O. Shablykin, O. Shablykina, V. Brovarets","doi":"10.15407/bioorganica2021.01.010","DOIUrl":null,"url":null,"abstract":"A number of sulfamides were obtained by reaction of (5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride with anilines, benzylamines, Boc-protected piperazine, methylalylamine, and amino acids methyl esters with primary and secondary amino group. The antiviral and anticancer activity of new derivatives was evaluated. The most effective compounds against Human cytomegalovirus were sulfamides based on anisidine (1b), N-Boc-piperazine (1h), and the derivatives 1n,o with fragments of nipecotic and azetidine-3-carboxylic acids, respectively. Anticancer activity was most significant for sulfamides based on p-methoxybenzylamine (compound 1d), benzylmethylamine (compound 1f), and allylmethylamine (compound 1g).","PeriodicalId":23438,"journal":{"name":"Ukr. Bioorg. Acta 2021, Vol. 16, N1","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"New 4-iminohydantoin sulfamide derivatives with antiviral and anticancer activity\",\"authors\":\"Y. Kornii, O. Shablykin, O. Shablykina, V. Brovarets\",\"doi\":\"10.15407/bioorganica2021.01.010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A number of sulfamides were obtained by reaction of (5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride with anilines, benzylamines, Boc-protected piperazine, methylalylamine, and amino acids methyl esters with primary and secondary amino group. The antiviral and anticancer activity of new derivatives was evaluated. The most effective compounds against Human cytomegalovirus were sulfamides based on anisidine (1b), N-Boc-piperazine (1h), and the derivatives 1n,o with fragments of nipecotic and azetidine-3-carboxylic acids, respectively. Anticancer activity was most significant for sulfamides based on p-methoxybenzylamine (compound 1d), benzylmethylamine (compound 1f), and allylmethylamine (compound 1g).\",\"PeriodicalId\":23438,\"journal\":{\"name\":\"Ukr. Bioorg. Acta 2021, Vol. 16, N1\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ukr. Bioorg. Acta 2021, Vol. 16, N1\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15407/bioorganica2021.01.010\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ukr. Bioorg. Acta 2021, Vol. 16, N1","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15407/bioorganica2021.01.010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

以(5-(二氯乙烯)-2-氧咪唑烷-4-酰基)磺胺酰氯与苯胺、苄胺、boc保护哌嗪、甲基乙胺、氨基酸甲酯与叔胺基和仲胺基反应得到了多种磺胺。评价了新衍生物的抗病毒和抗癌活性。对人巨细胞病毒最有效的化合物分别是以茴香胺(1b)、n - boc -哌嗪(1h)为基础的磺胺类化合物,以及以硝基苯胺和氮杂啶-3-羧酸片段为基础的衍生物1n、0。以对甲氧基苄胺(化合物1d)、苄基甲胺(化合物1f)和烯丙基甲胺(化合物1g)为基础的磺胺类化合物的抗癌活性最为显著。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New 4-iminohydantoin sulfamide derivatives with antiviral and anticancer activity
A number of sulfamides were obtained by reaction of (5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride with anilines, benzylamines, Boc-protected piperazine, methylalylamine, and amino acids methyl esters with primary and secondary amino group. The antiviral and anticancer activity of new derivatives was evaluated. The most effective compounds against Human cytomegalovirus were sulfamides based on anisidine (1b), N-Boc-piperazine (1h), and the derivatives 1n,o with fragments of nipecotic and azetidine-3-carboxylic acids, respectively. Anticancer activity was most significant for sulfamides based on p-methoxybenzylamine (compound 1d), benzylmethylamine (compound 1f), and allylmethylamine (compound 1g).
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信