A. Zavrazhnova, E. Kuvardin, V. Myachikova, A. Khadgidis, N. Anokhina, M. Anriyanova, Y. Kozlova, A. Maslyanskiy
{"title":"成人发病斯蒂尔氏病患者的靶向治疗挑战","authors":"A. Zavrazhnova, E. Kuvardin, V. Myachikova, A. Khadgidis, N. Anokhina, M. Anriyanova, Y. Kozlova, A. Maslyanskiy","doi":"10.32756/0869-5490-2023-2-51-58","DOIUrl":null,"url":null,"abstract":"Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disease mediated by interleukin (IL)-1 production. There are no treatment guidelines for AOSD due to its rarity and heterogenous manifestations. Therefore, each case is challenging and requires a multidisciplinary approach. We report a case of AOSD occurring in pregnant patient who did not respond to standard treatment with glucocorticoids and developed skin reaction to IL-1 receptor antagonist. However, drug desensibilisation was effective and allowed to continue treatment with anakinra.","PeriodicalId":10353,"journal":{"name":"Clinical pharmacology and therapy","volume":"68 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Targeted treatment challenges in patients with adult-onset Still’s disease\",\"authors\":\"A. Zavrazhnova, E. Kuvardin, V. Myachikova, A. Khadgidis, N. Anokhina, M. Anriyanova, Y. Kozlova, A. Maslyanskiy\",\"doi\":\"10.32756/0869-5490-2023-2-51-58\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disease mediated by interleukin (IL)-1 production. There are no treatment guidelines for AOSD due to its rarity and heterogenous manifestations. Therefore, each case is challenging and requires a multidisciplinary approach. We report a case of AOSD occurring in pregnant patient who did not respond to standard treatment with glucocorticoids and developed skin reaction to IL-1 receptor antagonist. However, drug desensibilisation was effective and allowed to continue treatment with anakinra.\",\"PeriodicalId\":10353,\"journal\":{\"name\":\"Clinical pharmacology and therapy\",\"volume\":\"68 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical pharmacology and therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32756/0869-5490-2023-2-51-58\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical pharmacology and therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32756/0869-5490-2023-2-51-58","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Targeted treatment challenges in patients with adult-onset Still’s disease
Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disease mediated by interleukin (IL)-1 production. There are no treatment guidelines for AOSD due to its rarity and heterogenous manifestations. Therefore, each case is challenging and requires a multidisciplinary approach. We report a case of AOSD occurring in pregnant patient who did not respond to standard treatment with glucocorticoids and developed skin reaction to IL-1 receptor antagonist. However, drug desensibilisation was effective and allowed to continue treatment with anakinra.
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