在没有心脏外科的医院进行经导管主动脉瓣介入治疗:未来的前景?

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2024-04-01 Epub Date: 2022-06-10 DOI:10.23736/S2724-5683.22.06076-8
Stefano Rigattieri, Chiara Bernelli, Francesco Tomassini, Giorgio Caretta, Shahram Moshiri, Andrea Berni, Ferdinando Varbella, Alberto Menozzi
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引用次数: 0

摘要

经导管主动脉瓣介入术(TAVI)于 2000 年初问世,为无法手术的严重主动脉瓣狭窄患者提供治疗。几十年后,该手术对中低手术风险患者也变得有效和安全;因此,由于人口逐渐老龄化,对经导管主动脉瓣介入手术的临床需求不断增加,而手术的可用性(即所谓的 "TAVI 容量")却难以满足这种需求。因此,许多患者在转诊至 TAVI 中心时遇到困难,或面临漫长的候诊时间,从而有可能在手术实施前发生严重的不良事件(包括死亡)。尽管当代指南和共识文件建议,TAVI 只应在设有心脏外科的医院进行,但在没有心脏外科的心脏介入实验室也开展 TAVI 项目,不失为一种提高 TAVI 容量的方法,从而使更多患者在更短的时间内得到治疗。但从另一个角度来看,这种策略可能会危及患者的安全,因为一旦出现围手术期并发症,就需要进行救助手术,并可能导致多学科心脏团队的评估效果不理想。本综述旨在评估和讨论现有的临床数据,以及考虑到日益增长的未满足临床需求和 TAVI 平台的技术进步,在未设立心脏外科的医院实施 TAVI 项目的情况,同时也不忽视国际科学协会的建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transcatheter aortic valve intervention in hospitals without cardiac surgery departments: a future scenario?

Transcatheter aortic valve intervention (TAVI) was introduced in early 2000 to offer treatment to inoperable patients with severe aortic valve stenosis. In a couple of decades, the procedure resulted effective and safe also in patients with intermediate to low risk for surgery; therefore, due to the progressive ageing of the population, the clinical need for TAVI is continuously increasing and is hardly met by the availability of the procedure, the so-called "TAVI capacity". As a result, many patients encounter difficulties in being referred to TAVI centers or face long waiting list times, thus risking severe adverse events (including death) before the procedure is performed. Although contemporary guidelines and consensus documents recommend that TAVI should only be performed in hospitals with active cardiac surgery departments, starting TAVI programs also in interventional cardiac laboratories without on-site cardiac surgery could represent a way to increase TAVI capacity, thus leading to a greater number of patients being treated in less time. On the other side of the coin, such a strategy may jeopardize patient safety in case of periprocedural complications needing bailout surgery and may lead to a suboptimal multidisciplinary Heart Team evaluation. This review aims to assess and discuss available clinical data and implementation of TAVI programs in hospitals without on-site active cardiac surgery departments considering the growing unmet clinical need and technical advancement of TAVI platforms, yet not overlooking the recommendations of international scientific societies.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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