长链非编码RNA (TUG1)在系统性红斑狼疮中的分子评价

Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology Pub Date : 2023-06-08 DOI:10.21608/eajbsc.2023.303332

S. Ramadan, W. Shousha, O. Shaker, N. Ahmed, S. Abdo

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引用次数: 0

摘要

长链非编码rna在系统性红斑狼疮中起重要作用。我们的工作目的是评估SLE患者的LNC (TUG1)水平。本研究包括20名对照组和70名SLE受试者。采用聚合酶链反应测定血清LNC (TUG1)水平。LNC (TUG1)在SLE患者中的下调表达高于对照组。TUG1水平的AUC值显著，提示TUG1可作为SLE检测的新的生物标志物。

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Molecular Evaluation of Long Non-Coding RNA (TUG1) in Systemic Lupus Erythematosus

Long non-coding RNAs play an important role in systemic lupus erythematosus. Our work purpose is to evaluate the level of LNC (TUG1) in SLE patients. This research includes 20 control and 70 SLE subjects. The serum level of LNC (TUG1) was measured by polymerase chain reaction. Down-expression of LNC (TUG1) was observed in SLE patients more than in control. A significant AUC of TUG1 level was recorded, which recommended that (TUG1) can act as a new biomarker for SLE determination .

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Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology

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