ABH分泌状态的频率:尼日利亚西南部拉各斯的横断面研究

S. Fakorede, Sulaimon A. Salami, Khalid Olajide Adekoya, B. Oboh
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引用次数: 0

摘要

粘膜含有ABO血型系统的可溶性抗原。分泌状态作为一种特征与多种临床疾病有关,并由个体的聚焦转移酶2 (FUT2)等位基因决定。与ABO血型表型相关的分泌状态分布因地区而异,具有医学意义。关于所研究人群的分泌物状况的信息缺乏。本研究的目的是评估尼日利亚人口中ABH的分泌状况。为此,从拉各斯市区325名(181名男性和144名女性)明显健康的个体中采集了新鲜唾液样本(~5 ml)。分泌状态由血凝抑制试验确定与参与者的唾液样本。结果显示,85%的受试者为分泌物,15%的受试者为非分泌物,男女性别差异无统计学意义(p>0.05)。Secretor、Se和Non-secretor、Se基因的频率分别为0.543和0.457,而SeSe、SeSe和SeSe基因型的频率分别为0.294、0.496和0.209。受试者ABO血型分布为:O组65.5%,A组16.6%,B组15.1%,AB组2.8%,各血型间分泌物发生率分别为:O组89%,A组85%,B组79%,AB组67%,但各血型间分泌物状况及ABO血型差异无统计学意义(p>0.05)。综上所述,本研究表明,分泌者多于非分泌者,且分泌ABH抗原的能力独立于个体的ABO血。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Frequency of ABH secretor status: a cross-sectional study in Lagos, Southwestern Nigeria
Abstract The mucosa contains soluble antigens of the ABO blood group system. Secretor status as a trait has been linked to a variety of clinical diseases and is determined by the individual’s fucosyltransferase 2 (FUT2) allele. The distribution of secretor status in relation to ABO blood group phenotypes varies from region to region, with medicolegal significance. There is a dearth of information on the secretor status of the studied population. The aim of the present study was to evaluate the secretor status of the ABH in a Nigerian population. To achieve this, fresh saliva samples (~5 ml) were collected from 325 (181 males and 144 females) apparently healthy individuals in the urban city of Lagos. Secretor status was determined by haemagglutination inhibition test with the saliva samples of participants. Results showed that 85% of the participants were secretors and 15% were non-secretors with no statistically significant differences (p>0.05) between male and female gender. The frequencies of the Secretor, Se and Non-secretor, se genes were 0.543 and 0.457, respectively while the frequencies of the SeSe, Sese, and sese genotypes were 0.294, 0.496, and 0.209, respectively. The participants’ ABO blood group distributions were 65.5% group O, 16.6% group A, 15.1% group B, and 2.8% group AB. The incidence of secretors across blood group was 89% in group O, 85% in A, 79% in B and 67% in AB. However, there were no statistically significant variations in secretor status and ABO blood group (p>0.05). In conclusion, the study shows that there are more secretors than non-secretors, and the ability to secrete the ABH antigens are independent of ABO blood of individuals.
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