{"title":"外atp酶对嘌呤能神经传递的调节","authors":"Charles Kennedy, Tim D. Westfall, Peter Sneddon","doi":"10.1006/smns.1996.0025","DOIUrl":null,"url":null,"abstract":"<div><p>The role of ecto-ATPase in modulating the purinergic component of neurotransmission in the guinea-pig vas deferens has been investigated using ARL 67156, a recently developed inhibitor of ecto-ATPase. ARL 67156 rapidly and reversibly potentiated neurogenic contractions in a concentration-dependent manner. ARL 67156 also potentiated contractions evoked by exogenous ATP, but had no effect on those to the stable analogue α,β-methyleneATP or on those to noradrenaline and KCl in the presence of the P<sub>2</sub>-purinoceptor antagonist PPADS. These results are consistent with an inhibitory action of ARL 67156 on ecto-ATPase and suggest that ecto-ATPase modulates purinergic neurotransmission in the guinea-pig vas deferens.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 4","pages":"Pages 195-199"},"PeriodicalIF":0.0000,"publicationDate":"1996-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0025","citationCount":"21","resultStr":"{\"title\":\"Modulation of purinergic neurotransmission by ecto-ATPase\",\"authors\":\"Charles Kennedy, Tim D. Westfall, Peter Sneddon\",\"doi\":\"10.1006/smns.1996.0025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The role of ecto-ATPase in modulating the purinergic component of neurotransmission in the guinea-pig vas deferens has been investigated using ARL 67156, a recently developed inhibitor of ecto-ATPase. ARL 67156 rapidly and reversibly potentiated neurogenic contractions in a concentration-dependent manner. ARL 67156 also potentiated contractions evoked by exogenous ATP, but had no effect on those to the stable analogue α,β-methyleneATP or on those to noradrenaline and KCl in the presence of the P<sub>2</sub>-purinoceptor antagonist PPADS. These results are consistent with an inhibitory action of ARL 67156 on ecto-ATPase and suggest that ecto-ATPase modulates purinergic neurotransmission in the guinea-pig vas deferens.</p></div>\",\"PeriodicalId\":101157,\"journal\":{\"name\":\"Seminars in Neuroscience\",\"volume\":\"8 4\",\"pages\":\"Pages 195-199\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1006/smns.1996.0025\",\"citationCount\":\"21\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in Neuroscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1044576596900251\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1044576596900251","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Modulation of purinergic neurotransmission by ecto-ATPase
The role of ecto-ATPase in modulating the purinergic component of neurotransmission in the guinea-pig vas deferens has been investigated using ARL 67156, a recently developed inhibitor of ecto-ATPase. ARL 67156 rapidly and reversibly potentiated neurogenic contractions in a concentration-dependent manner. ARL 67156 also potentiated contractions evoked by exogenous ATP, but had no effect on those to the stable analogue α,β-methyleneATP or on those to noradrenaline and KCl in the presence of the P2-purinoceptor antagonist PPADS. These results are consistent with an inhibitory action of ARL 67156 on ecto-ATPase and suggest that ecto-ATPase modulates purinergic neurotransmission in the guinea-pig vas deferens.
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