A. Dawidar, M. Abou-Elzahab, M. Berghot, K. H. AI-Maah
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Photooxygenation of β-sitosterol and stigmasterol and DNA-damaging properties of their hydroperoxide products
The phytosterol β-sitosterol (1), its acetate derivative (3) and stigmasterol (2) were photo-oxygenated using tetraphenyl porphorin (TPP) or rose Bengal (RB) and sensitizer in different solvents to give hydroperoxides 4,8 and dihydroperoxide 7, respectively. Structures 4,8 and 7 were elucidated on the basis of spectral data from their 1H NMR, MS and IR spectra. Product 7 produced moderate DNA degradation, but 4 did not.
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