Triester glycerol oxide in the treatment of recurrent aphthous stomatitis: A cytological investigation

Abstract Aim: The objective of the present study was to evaluate the clinical and cytological effects of a new topical gel, (Protefix) with triester glycerol oxide (TGO) on recurrent aphthous stomatitis (RAS). Method: In this study, 50 patients referred to the Department of Oral Diagnosis and Radiology, Marmara University, Faculty of Dentistry, were studied. A clinical examination, a complete review of past medical history, and a detailed history of RAS was performed in each patient. Clinical features of apthous ulcers and visual analogue scale values scraped (VAS) were recorded. Cytological examination was performed by collecting smear material scraped off the lesion surface. Triester glycerol oxide (TGO) gel (Protefix®, Queisser Pharma) was applied to lesions three times a day. Results: A significant reduction of the number of erythrocytes and inflammatory cells, and a significant increase of mature epithelial cells were observed. Conclusions: This treatment may be used as an initial strategy for reduct...