肠易激综合征儿童的心率变异性和特质焦虑:有联系吗?

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
M. Semen, O. Lychkovska, V. Şemen, O. P. Yelisieieva
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引用次数: 1

摘要

的目标。本研究的目的是评估肠易激综合征儿童心率变异性参数及其与焦虑水平的相关性。材料和方法。我们招募了22名6-12岁的儿童,根据Rome标准IV确诊为肠易激综合征。对照组包括10名相同年龄和性别的儿童。采用CMAS (Children’s Manifest Anxiety Scale)测验评估特质焦虑水平。心率变异性的非侵入性方法被用作神经体液调节的跨诊断生物标志物,从而用于抗逆性。研究了平卧位5min心电图记录心率变异性的时频域参数。数据采用Microsoft Excel 2016处理,GraphPad (Prism 5.0)软件进行分析。与对照组相比,患有肠易激综合征的儿童的特质焦虑水平高出1.7倍,心率变异性参数值低2.2倍。此外,交感神经(LF)活性的降低伴随着神经体液成分(VLF)和副交感神经(HF)活性的上调。肠易激综合征患儿心率变异性参数与特质焦虑呈正相关。患有肠易激综合症的儿童表现出更高水平的特质焦虑。心率变异性的降低及其频谱结构的改变提示肠-脑轴失调,自主神经活动减少,神经体液调节为主。总之,我们的研究为儿童肠易激综合征的病理生理学提供了重要信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Heart rate variability and trait anxiety in children with irritable bowel syndrome: is there a link?
Aim. The aim of current study was to evaluate parameters of heart rate variability and their correlation with the levels of anxiety in children with irritable bowel syndrome. Materials and methods. We enrolled 22 children aged 6–12 years with verified diagnosis of irritable bowel syndrome according to the Rome criteria IV. The control group included 10 children of the same age and sex. The CMAS (Children’s Manifest Anxiety Scale) test was used for evaluation of the trait anxiety level. A non-invasive method of heart rate variability is used as a transdiagnostic biomarker of neurohumoral regulation and, thus, of the stress resistance. Time and frequency domain parameters of heart rate variability were studied in 5 min ECG-recordings in supine position. Data were processed using Microsoft Excel 2016 and analyzed with GraphPad (Prism 5.0). Results. Children with irritable bowel syndrome had significantly 1.7-fold higher levels of trait anxiety and 2.2-fold lower values of heart rate variability parameters as compared to the control group. In addition, reduced sympathetic (LF) activity was accompanied by upregulation of neurohumoral component (VLF) and parasympathetic (HF) activity. A positive correlation between parameters of heart rate variability and trait anxiety was found in children with irritable bowel syndrome. Conclusions. Children with irritable bowel syndrome were shown with increased levels of trait anxiety. Reduction in heart rate variability and changes of its spectral structure were suggestive about the dysregulation in the gut-brain axis with reduction of the autonomic activity and predominance of neurohumoral regulation. In summary, our study has provided important information about the pathophysiology of irritable bowel syndrome in children.  
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来源期刊
Zaporozhye Medical Journal
Zaporozhye Medical Journal MEDICINE, GENERAL & INTERNAL-
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审稿时长
8 weeks
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