肠道生态失调在2型糖尿病中的病理生理作用及益生菌、益生元和粪便微生物群移植的抗糖尿病潜力

K. Aitbaev, I. T. Murkamilov, Z. Murkamilova, V. Fomin, I. Kudaibergenova, T. F. Yusupova, F. Yusupov
{"title":"肠道生态失调在2型糖尿病中的病理生理作用及益生菌、益生元和粪便微生物群移植的抗糖尿病潜力","authors":"K. Aitbaev, I. T. Murkamilov, Z. Murkamilova, V. Fomin, I. Kudaibergenova, T. F. Yusupova, F. Yusupov","doi":"10.30629/0023-2149-2023-101-4-5-188-193","DOIUrl":null,"url":null,"abstract":"Type 2 diabetes mellitus (DM2) is a multifactorial disease, and obesity plays the key role in the development thereof. It is believed that the global rise in vast proliferation of DM2 and obesity, recently viewed as an epidemic, is caused by urbanization, reduced physical activity and widely available high-calorie food. Recently, another “player” in the pathophysiology of type 2 diabetes mellitus has been discovered — the intestinal microbiota (IM). Numerous studies have shown the connection between the development of type 2 diabetes mellitus and IM. The review discusses the mechanisms, through which IM contributes to the development of DM2. The results of experimental and clinical studies on the eff ectiveness of the use of probiotics, prebiotics and fecal microbiota transplantation as a method of prevention and treatment of type 2 diabetes mellitus are given.","PeriodicalId":10439,"journal":{"name":"Clinical Medicine (Russian Journal)","volume":"1528 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The pathophysiological role of intestinal dysbiosis in type 2 diabetes mellitus and the anti-diabetic potential of probiotics, prebiotics and fecal microbiota transplantation\",\"authors\":\"K. Aitbaev, I. T. Murkamilov, Z. Murkamilova, V. Fomin, I. Kudaibergenova, T. F. Yusupova, F. Yusupov\",\"doi\":\"10.30629/0023-2149-2023-101-4-5-188-193\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Type 2 diabetes mellitus (DM2) is a multifactorial disease, and obesity plays the key role in the development thereof. It is believed that the global rise in vast proliferation of DM2 and obesity, recently viewed as an epidemic, is caused by urbanization, reduced physical activity and widely available high-calorie food. Recently, another “player” in the pathophysiology of type 2 diabetes mellitus has been discovered — the intestinal microbiota (IM). Numerous studies have shown the connection between the development of type 2 diabetes mellitus and IM. The review discusses the mechanisms, through which IM contributes to the development of DM2. The results of experimental and clinical studies on the eff ectiveness of the use of probiotics, prebiotics and fecal microbiota transplantation as a method of prevention and treatment of type 2 diabetes mellitus are given.\",\"PeriodicalId\":10439,\"journal\":{\"name\":\"Clinical Medicine (Russian Journal)\",\"volume\":\"1528 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-05-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Medicine (Russian Journal)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.30629/0023-2149-2023-101-4-5-188-193\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Medicine (Russian Journal)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30629/0023-2149-2023-101-4-5-188-193","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

2型糖尿病(DM2)是一种多因素疾病,肥胖在其发病过程中起着关键作用。人们认为,最近被视为一种流行病的DM2和肥胖在全球范围内的大规模扩散是城市化、体力活动减少和高热量食物的广泛供应造成的。最近,在2型糖尿病的病理生理中发现了另一个“玩家”——肠道微生物群(IM)。大量研究表明,2型糖尿病的发展与IM之间存在联系。本文讨论了IM促进DM2发展的机制。本文给出了利用益生菌、益生元和粪便菌群移植防治2型糖尿病的有效性的实验和临床研究结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The pathophysiological role of intestinal dysbiosis in type 2 diabetes mellitus and the anti-diabetic potential of probiotics, prebiotics and fecal microbiota transplantation
Type 2 diabetes mellitus (DM2) is a multifactorial disease, and obesity plays the key role in the development thereof. It is believed that the global rise in vast proliferation of DM2 and obesity, recently viewed as an epidemic, is caused by urbanization, reduced physical activity and widely available high-calorie food. Recently, another “player” in the pathophysiology of type 2 diabetes mellitus has been discovered — the intestinal microbiota (IM). Numerous studies have shown the connection between the development of type 2 diabetes mellitus and IM. The review discusses the mechanisms, through which IM contributes to the development of DM2. The results of experimental and clinical studies on the eff ectiveness of the use of probiotics, prebiotics and fecal microbiota transplantation as a method of prevention and treatment of type 2 diabetes mellitus are given.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信