A. Bortone, J. Albenque, F. D. Ramirez, M. Haïssaguerre, S. Combes, M. Constantin, Guillaume Laborie, G. Brault-Noble, É. Marijon, P. Jaïs, T. Pambrun
{"title":"90 vs 50瓦的肺静脉隔离射频应用:实验和临床发现","authors":"A. Bortone, J. Albenque, F. D. Ramirez, M. Haïssaguerre, S. Combes, M. Constantin, Guillaume Laborie, G. Brault-Noble, É. Marijon, P. Jaïs, T. Pambrun","doi":"10.1161/CIRCEP.121.010663","DOIUrl":null,"url":null,"abstract":"Background: Fifty-watt radiofrequency applications have proven to be safe and efficient for pulmonary vein isolation (PVI). However, as PV reconnection still occurs and ablation catheter instability significantly contributes to suboptimal lesion formation, a new ablation catheter capable of delivering 90 W for 4 seconds only has been developed with the aim of improving PVI outcomes. In this setting, we sought to determine whether 90 W applications create transmural lesions without collateral damage experimentally and whether they can safely improve PVI procedures clinically compared with 50 W settings. Methods: Experimentally, individual lesions were created in vivo in the right atrium of 6 swine with 90 W-4 seconds applications using the SmartTouch-SF catheter in a power-controlled mode (3 animals) or the QDOT-MICRO catheter in a temperature-controlled mode (3 animals). Clinically, PVI was performed in a homogenous population of 150 consecutive paroxysmal atrial fibrillation patients using CARTO and the QDOT-MICRO catheter in a temperature-controlled mode (75 patients 50 W-ablation index-guided and 75 patients 90 W-4 seconds). Results: Mostly, (94.9%) experimental lesions were transmural in the thin-walled right atrium of swine. However, collateral damage was observed with both catheters in 17.9% of lesions. Clinically, 90 W procedures had a lower first-pass PVI rate (49% versus 81%, P<10−4) and a higher acute PV reconnection rate (21% versus 5%, P=0.004) than 50 W procedures, whereas total procedural duration (62 versus 66 minutes, P=0.09), 1-year sinus rhythm maintenance (88% versus 90%, P=0.6) and safety (1 tamponade per group) were similar in both groups. Conclusions: Experimentally, using the QDOT-MICRO catheter, 90 W-4 seconds lesions are mostly transmural in the thin-walled right atrium of swine (median depth 1.87 mm) with a moderate lesion diameter of 6.62 mm but retain the potential for collateral damage. Clinically, 90 W-4 seconds applications are associated with a lower first-pass PVI rate and a higher acute PV reconnection rate than 50 W applications but similar safety outcomes and effectiveness at 1 year.","PeriodicalId":10167,"journal":{"name":"Circulation: Arrhythmia and Electrophysiology","volume":"45 1","pages":"e010663"},"PeriodicalIF":0.0000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"20","resultStr":"{\"title\":\"90 vs 50-Watt Radiofrequency Applications for Pulmonary Vein Isolation: Experimental and Clinical Findings\",\"authors\":\"A. Bortone, J. Albenque, F. D. Ramirez, M. Haïssaguerre, S. Combes, M. Constantin, Guillaume Laborie, G. Brault-Noble, É. Marijon, P. Jaïs, T. Pambrun\",\"doi\":\"10.1161/CIRCEP.121.010663\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Fifty-watt radiofrequency applications have proven to be safe and efficient for pulmonary vein isolation (PVI). However, as PV reconnection still occurs and ablation catheter instability significantly contributes to suboptimal lesion formation, a new ablation catheter capable of delivering 90 W for 4 seconds only has been developed with the aim of improving PVI outcomes. In this setting, we sought to determine whether 90 W applications create transmural lesions without collateral damage experimentally and whether they can safely improve PVI procedures clinically compared with 50 W settings. Methods: Experimentally, individual lesions were created in vivo in the right atrium of 6 swine with 90 W-4 seconds applications using the SmartTouch-SF catheter in a power-controlled mode (3 animals) or the QDOT-MICRO catheter in a temperature-controlled mode (3 animals). Clinically, PVI was performed in a homogenous population of 150 consecutive paroxysmal atrial fibrillation patients using CARTO and the QDOT-MICRO catheter in a temperature-controlled mode (75 patients 50 W-ablation index-guided and 75 patients 90 W-4 seconds). Results: Mostly, (94.9%) experimental lesions were transmural in the thin-walled right atrium of swine. However, collateral damage was observed with both catheters in 17.9% of lesions. Clinically, 90 W procedures had a lower first-pass PVI rate (49% versus 81%, P<10−4) and a higher acute PV reconnection rate (21% versus 5%, P=0.004) than 50 W procedures, whereas total procedural duration (62 versus 66 minutes, P=0.09), 1-year sinus rhythm maintenance (88% versus 90%, P=0.6) and safety (1 tamponade per group) were similar in both groups. Conclusions: Experimentally, using the QDOT-MICRO catheter, 90 W-4 seconds lesions are mostly transmural in the thin-walled right atrium of swine (median depth 1.87 mm) with a moderate lesion diameter of 6.62 mm but retain the potential for collateral damage. 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引用次数: 20
摘要
背景:50瓦射频应用已被证明是安全有效的肺静脉隔离(PVI)。然而,由于PV重连仍然会发生,消融导管的不稳定性显著导致病变形成不理想,为了改善PVI结果,一种新的消融导管能够在4秒内提供90w的能量。在这种情况下,我们试图确定90w是否会在实验中产生无附带损伤的跨壁病变,以及与50w设置相比,它们是否可以安全地改善临床PVI手术。方法:实验中,使用SmartTouch-SF导管在功率控制模式下(3只动物)或QDOT-MICRO导管在温度控制模式下(3只动物),在6头猪的右心房进行90 W-4秒的应用,在体内形成单个病变。临床上,在150例连续阵发性心房颤动患者中使用CARTO和QDOT-MICRO导管在温控模式下进行PVI(75例患者50 w -消融指数引导,75例患者90 W-4秒)。结果:猪右心房薄壁病变多为跨壁病变(94.9%)。然而,17.9%的病变观察到两根导管的附带损伤。临床上,90w手术比50w手术具有更低的首次通过PVI率(49%比81%,P<10−4)和更高的急性PV重连率(21%比5%,P=0.004),而两组的总手术时间(62比66分钟,P=0.09)、1年窦性心律维持(88%比90%,P=0.6)和安全性(每组1次填塞)相似。结论:在实验中,使用QDOT-MICRO导管,90 W-4秒的病变主要是跨壁的猪右心房薄壁病变(中位深度1.87 mm),中度病变直径为6.62 mm,但保留了附带损伤的可能性。临床上,90w -4秒的应用与50w的应用相比,具有较低的首次通过PV率和较高的急性PV重新连接率,但在1年的安全性和有效性相似。
90 vs 50-Watt Radiofrequency Applications for Pulmonary Vein Isolation: Experimental and Clinical Findings
Background: Fifty-watt radiofrequency applications have proven to be safe and efficient for pulmonary vein isolation (PVI). However, as PV reconnection still occurs and ablation catheter instability significantly contributes to suboptimal lesion formation, a new ablation catheter capable of delivering 90 W for 4 seconds only has been developed with the aim of improving PVI outcomes. In this setting, we sought to determine whether 90 W applications create transmural lesions without collateral damage experimentally and whether they can safely improve PVI procedures clinically compared with 50 W settings. Methods: Experimentally, individual lesions were created in vivo in the right atrium of 6 swine with 90 W-4 seconds applications using the SmartTouch-SF catheter in a power-controlled mode (3 animals) or the QDOT-MICRO catheter in a temperature-controlled mode (3 animals). Clinically, PVI was performed in a homogenous population of 150 consecutive paroxysmal atrial fibrillation patients using CARTO and the QDOT-MICRO catheter in a temperature-controlled mode (75 patients 50 W-ablation index-guided and 75 patients 90 W-4 seconds). Results: Mostly, (94.9%) experimental lesions were transmural in the thin-walled right atrium of swine. However, collateral damage was observed with both catheters in 17.9% of lesions. Clinically, 90 W procedures had a lower first-pass PVI rate (49% versus 81%, P<10−4) and a higher acute PV reconnection rate (21% versus 5%, P=0.004) than 50 W procedures, whereas total procedural duration (62 versus 66 minutes, P=0.09), 1-year sinus rhythm maintenance (88% versus 90%, P=0.6) and safety (1 tamponade per group) were similar in both groups. Conclusions: Experimentally, using the QDOT-MICRO catheter, 90 W-4 seconds lesions are mostly transmural in the thin-walled right atrium of swine (median depth 1.87 mm) with a moderate lesion diameter of 6.62 mm but retain the potential for collateral damage. Clinically, 90 W-4 seconds applications are associated with a lower first-pass PVI rate and a higher acute PV reconnection rate than 50 W applications but similar safety outcomes and effectiveness at 1 year.