羟基磷灰石和银的抗菌作用

Annals Series on History and Archaeology Academy of Romanian Scientists Pub Date : 2022-01-01 DOI:10.56082/annalsarsciphyschem.2022.2.7

Alexandra Avram, A. Mocanu, O. Horovitz, G. Tomoaia, M. Tomoaia-Cotisel

{"title":"羟基磷灰石和银的抗菌作用","authors":"Alexandra Avram, A. Mocanu, O. Horovitz, G. Tomoaia, M. Tomoaia-Cotisel","doi":"10.56082/annalsarsciphyschem.2022.2.7","DOIUrl":null,"url":null,"abstract":"Synthetic hydroxyapatite (Ca10(PO4)6(OH)2, HAP) is widely used in regards to orthopedic applications due to its similarity to the mineral component in bone. However, while HAP aids with osseointegration it does nothing when it comes to orthopedic infections. Moreover, the prevalence of antibiotic resistance makes treatment even more difficult. In view of this, adding silver to hydroxyapatite has been a focus of many studies due to the combined bioactivity of HAP and excellent antibacterial properties of Ag. The present work brings a brief introduction to more recent studies regarding the HAP-silver combination and its effect on different pathogenic strains. The effect of silver on benign cells is also discussed based on in vitro cultures and in vivo studies.","PeriodicalId":32445,"journal":{"name":"Annals Series on History and Archaeology Academy of Romanian Scientists","volume":"27 21 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ANTIBACTERIAL EFFECT OF HYDROXYAPATITE AND SILVER\",\"authors\":\"Alexandra Avram, A. Mocanu, O. Horovitz, G. Tomoaia, M. Tomoaia-Cotisel\",\"doi\":\"10.56082/annalsarsciphyschem.2022.2.7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Synthetic hydroxyapatite (Ca10(PO4)6(OH)2, HAP) is widely used in regards to orthopedic applications due to its similarity to the mineral component in bone. However, while HAP aids with osseointegration it does nothing when it comes to orthopedic infections. Moreover, the prevalence of antibiotic resistance makes treatment even more difficult. In view of this, adding silver to hydroxyapatite has been a focus of many studies due to the combined bioactivity of HAP and excellent antibacterial properties of Ag. The present work brings a brief introduction to more recent studies regarding the HAP-silver combination and its effect on different pathogenic strains. The effect of silver on benign cells is also discussed based on in vitro cultures and in vivo studies.\",\"PeriodicalId\":32445,\"journal\":{\"name\":\"Annals Series on History and Archaeology Academy of Romanian Scientists\",\"volume\":\"27 21 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals Series on History and Archaeology Academy of Romanian Scientists\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.56082/annalsarsciphyschem.2022.2.7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals Series on History and Archaeology Academy of Romanian Scientists","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.56082/annalsarsciphyschem.2022.2.7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

合成羟基磷灰石(Ca10(PO4)6(OH)2, HAP)因其与骨中的矿物成分相似而广泛应用于骨科。然而，虽然HAP有助于骨整合，但在骨科感染方面却没有任何作用。此外，抗生素耐药性的普遍存在使得治疗更加困难。鉴于此，将银加入羟基磷灰石中，由于HAP的联合生物活性和Ag优异的抗菌性能，已成为众多研究的热点。本文简要介绍了近年来关于hap -银组合及其对不同病原菌的作用的研究。在体外培养和体内研究的基础上，讨论了银对良性细胞的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

ANTIBACTERIAL EFFECT OF HYDROXYAPATITE AND SILVER

Synthetic hydroxyapatite (Ca10(PO4)6(OH)2, HAP) is widely used in regards to orthopedic applications due to its similarity to the mineral component in bone. However, while HAP aids with osseointegration it does nothing when it comes to orthopedic infections. Moreover, the prevalence of antibiotic resistance makes treatment even more difficult. In view of this, adding silver to hydroxyapatite has been a focus of many studies due to the combined bioactivity of HAP and excellent antibacterial properties of Ag. The present work brings a brief introduction to more recent studies regarding the HAP-silver combination and its effect on different pathogenic strains. The effect of silver on benign cells is also discussed based on in vitro cultures and in vivo studies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Annals Series on History and Archaeology Academy of Romanian Scientists

自引率

0.00%

发文量

审稿时长

15 weeks