维生素C和E的摄入与对氧磷酶活性的增加有关

G. Jarvik, N. Tsai, Laura A. McKinstry, R. Wani, V. Brophy, R. Richter, G. Schellenberg, P. Heagerty, T. Hatsukami, C. Furlong
{"title":"维生素C和E的摄入与对氧磷酶活性的增加有关","authors":"G. Jarvik, N. Tsai, Laura A. McKinstry, R. Wani, V. Brophy, R. Richter, G. Schellenberg, P. Heagerty, T. Hatsukami, C. Furlong","doi":"10.1161/01.ATV.0000027101.40323.3A","DOIUrl":null,"url":null,"abstract":"Objective—Paraoxonase (PON1), an esterase physically associated with high density lipoprotein, has been shown to inhibit atherogenic low density lipoprotein and high density lipoprotein oxidation. PON1 activity appears to be primarily under genetic control with some environmental modification and is a predictor of vascular disease. Vitamins C and E, dietary antioxidants, scavenge free-oxygen radical products that may depress PON1 activity. Therefore, we evaluated the relationship between dietary vitamin C and E intake and PON1 activity. Methods and Results—The vitamin C and E intakes of male white subjects (n=189) were estimated by using a standardized food frequency survey. With covariates, vitamin C or E intakes were found to be significant positive predictors of PON1 activity for the hydrolysis of paraoxon and diazoxon with the use of linear regression. Smoking and use of statins were independent predictors of PON1 activity. Conclusions—PON1 activity, which is primarily genotype dependent, varies with antioxidant vitamins, cigarette smoking, and statin drug use. Because PON1 activity is a better predictor of vascular disease than is the currently described genetic variation in PON1, further studies of the environmental influences on PON1 activity and additional PON1 genetic variants are warranted.","PeriodicalId":8418,"journal":{"name":"Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association","volume":"10 1","pages":"1329-1333"},"PeriodicalIF":0.0000,"publicationDate":"2002-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"208","resultStr":"{\"title\":\"Vitamin C and E Intake Is Associated With Increased Paraoxonase Activity\",\"authors\":\"G. Jarvik, N. Tsai, Laura A. McKinstry, R. Wani, V. Brophy, R. Richter, G. Schellenberg, P. Heagerty, T. Hatsukami, C. Furlong\",\"doi\":\"10.1161/01.ATV.0000027101.40323.3A\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective—Paraoxonase (PON1), an esterase physically associated with high density lipoprotein, has been shown to inhibit atherogenic low density lipoprotein and high density lipoprotein oxidation. PON1 activity appears to be primarily under genetic control with some environmental modification and is a predictor of vascular disease. Vitamins C and E, dietary antioxidants, scavenge free-oxygen radical products that may depress PON1 activity. Therefore, we evaluated the relationship between dietary vitamin C and E intake and PON1 activity. Methods and Results—The vitamin C and E intakes of male white subjects (n=189) were estimated by using a standardized food frequency survey. With covariates, vitamin C or E intakes were found to be significant positive predictors of PON1 activity for the hydrolysis of paraoxon and diazoxon with the use of linear regression. Smoking and use of statins were independent predictors of PON1 activity. Conclusions—PON1 activity, which is primarily genotype dependent, varies with antioxidant vitamins, cigarette smoking, and statin drug use. Because PON1 activity is a better predictor of vascular disease than is the currently described genetic variation in PON1, further studies of the environmental influences on PON1 activity and additional PON1 genetic variants are warranted.\",\"PeriodicalId\":8418,\"journal\":{\"name\":\"Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association\",\"volume\":\"10 1\",\"pages\":\"1329-1333\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"208\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1161/01.ATV.0000027101.40323.3A\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1161/01.ATV.0000027101.40323.3A","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 208

摘要

目的:对氧磷酶(PON1)是一种与高密度脂蛋白物理相关的酯酶,已被证明可以抑制致动脉粥样硬化的低密度脂蛋白和高密度脂蛋白氧化。PON1活性似乎主要受遗传控制和一些环境改变,是血管疾病的预测因子。维生素C和E,膳食抗氧化剂,清除可能抑制PON1活性的自由基产物。因此,我们评估了膳食维生素C和E摄入量与PON1活性之间的关系。方法与结果:采用标准化食物频次调查法,对189名男性白人受试者的维生素C和E摄入量进行估算。在协变量方面,使用线性回归发现维生素C或E摄入量是PON1活性对对氧磷和重氮磷水解的显著正预测因子。吸烟和使用他汀类药物是PON1活性的独立预测因子。结论- pon1活性主要依赖于基因型,与抗氧化维生素、吸烟和他汀类药物使用有关。由于PON1活性比目前描述的PON1遗传变异更能预测血管疾病,因此需要进一步研究环境对PON1活性和其他PON1遗传变异的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vitamin C and E Intake Is Associated With Increased Paraoxonase Activity
Objective—Paraoxonase (PON1), an esterase physically associated with high density lipoprotein, has been shown to inhibit atherogenic low density lipoprotein and high density lipoprotein oxidation. PON1 activity appears to be primarily under genetic control with some environmental modification and is a predictor of vascular disease. Vitamins C and E, dietary antioxidants, scavenge free-oxygen radical products that may depress PON1 activity. Therefore, we evaluated the relationship between dietary vitamin C and E intake and PON1 activity. Methods and Results—The vitamin C and E intakes of male white subjects (n=189) were estimated by using a standardized food frequency survey. With covariates, vitamin C or E intakes were found to be significant positive predictors of PON1 activity for the hydrolysis of paraoxon and diazoxon with the use of linear regression. Smoking and use of statins were independent predictors of PON1 activity. Conclusions—PON1 activity, which is primarily genotype dependent, varies with antioxidant vitamins, cigarette smoking, and statin drug use. Because PON1 activity is a better predictor of vascular disease than is the currently described genetic variation in PON1, further studies of the environmental influences on PON1 activity and additional PON1 genetic variants are warranted.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信