铅暴露人群1型和2型免疫反应平衡的改变

Q2 Medicine

International Journal of Occupational and Environmental Health Pub Date : 2020-09-07 DOI:10.1183/13993003.CONGRESS-2020.1296

Y. Zakaria, Essam Abdel, M. Sherif

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引用次数: 1

摘要

一些研究报道了铅的免疫毒性作用。然而，在这些研究中，主要免疫细胞类型的明显细胞毒性并不明显，这表明铅可能会影响T -辅助性1 (Th1)和T -辅助性2 (Th)免疫反应细胞因子之间的平衡。本研究对这一假设进行了探讨。目的:研究环境铅暴露对研究对象血铅(B - Pb)水平的影响，探讨白细胞介素- 4 (IL - 4, Th2细胞因子之一)和γ干扰素(IFN - γ， Th1细胞因子之一)之间的平衡及其与铅暴露和B - Pb的关系。研究设计:本研究为横断面病例对照研究。原创研究文章

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Alteration in the balance between type 1 and type 2 immune responses among lead exposed population

Immunotoxic effect of lead was reported in several studies. However, overt cytotoxicity of major immune cell types was not evident in such studies and it was suggested that lead mig ht rather affect the balance between T - helper 1 (Th1) and T - helper 2 (Th) immune responses cytokines. Such hypothesis was investigated in the current study. Aims: To Study the effect of environmental exposure to lead on blood lead (B - Pb) level and to investigate the balance between interleukin - 4 (IL - 4, one of Th2 cytokines) and Gamma interferon (IFN - γ, one of Th1 cytokines) and its relation to lead exposure and B - Pb in the study subjects. Study Design : The study was designed to be cross - sectional case - control study. Original Research Article

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来源期刊

International Journal of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Cessation. International Journal of Occupational and Environmental Health ( IJOEH) is an authoritative, interdisciplinary resource covering occupational health, environmental health, and consumer health (the aspects of human disease and injury that are determined or influenced by exposure to consumer goods and their components, including pharmaceuticals, food additives, and other purchased products). It publishes original scientific and social scientific research, as well as commentary and analysis in the broad fields of occupational and environmental health. IJOEH is read by researchers, practitioners, policy makers, and activists in the fields of occupational, environmental, and consumer health. Its international readership extends across disciplines, including epidemiology, occupational and environmental medicine, sociology, toxicology, and related fields.