IDDF2021-ABS-0156 Sarcopenia associated with non-alcohol fatty liver disease (NAFLD) and fibrosis among adults in the United States: national health and nutrition examination survey (NHANES 2017–2018)

Mean values of Se intake and serum Se, tHg and MeHg were calculated; univariate and multi-variate linear regressions were conducted between CAP and Se intake, serum Se, tHg and MeHg, respectively with covariates of gender, age, ethnicity, tobacco smoke, BMI, educational level and average household income. Results Mean±SD for Se intake was 101.9±70.8 mcg, serum Se 2.4±0.33 nmol/L, serum tHg 5.6±11.4 nmol/L, serum MeHg 4.6±9.8 nmol/L, Se:tHg molar ratio of 1.1±0.8, Se: MeHg molar ratio of 1.5±1.0. The mean CAP was 257±66.2 dB/m. Univariate linear regression showed a positive association between CAP and Se intake (r=0.037, p<0.01), serum Se (r= 19.7, p<0.001), Se:MeHg molar ratio (r=-4.9, p<0.001), Se:tHg molar ratio (r= -2.8, p<0.001), respectively. After adjustment, associations between CAP and serum MeHg (r= 0.14, p<0.05), serum Se (r=13.8, p<0.001) remained statistically significant, but the associations with the molar ratios no longer existed. Conclusions Our results suggested that Se was associated with a decreased risk of NAFLD, whereas tHg and MeHg do not necessarily increase the disease risk. The molar ratios may present as early biomarkers for the prediction of NAFLD risk.