{"title":"氧化应激在肥胖相关肾损伤中的作用","authors":"D. Pierine, G. Biondo, V. S. Silva, C. Corrêa","doi":"10.14800/ICS.648","DOIUrl":null,"url":null,"abstract":"The mechanisms linking obesity to kidney damage are unknown. The kidney is a target organ for lesions caused by AGEs. The receptor of AGEs (RAGE) has proinflammatory stimuli and appears to play a role in the pathogenesis of renal disease. Thus, treatment with antioxidants can be beneficial for the prevention and therapy of oxidative stress and inflammation in the kidneys resulting from obesity.","PeriodicalId":13679,"journal":{"name":"Inflammation and cell signaling","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"The role of oxidative stress in renal injury related to obesity\",\"authors\":\"D. Pierine, G. Biondo, V. S. Silva, C. Corrêa\",\"doi\":\"10.14800/ICS.648\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The mechanisms linking obesity to kidney damage are unknown. The kidney is a target organ for lesions caused by AGEs. The receptor of AGEs (RAGE) has proinflammatory stimuli and appears to play a role in the pathogenesis of renal disease. Thus, treatment with antioxidants can be beneficial for the prevention and therapy of oxidative stress and inflammation in the kidneys resulting from obesity.\",\"PeriodicalId\":13679,\"journal\":{\"name\":\"Inflammation and cell signaling\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-03-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Inflammation and cell signaling\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14800/ICS.648\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inflammation and cell signaling","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14800/ICS.648","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The role of oxidative stress in renal injury related to obesity
The mechanisms linking obesity to kidney damage are unknown. The kidney is a target organ for lesions caused by AGEs. The receptor of AGEs (RAGE) has proinflammatory stimuli and appears to play a role in the pathogenesis of renal disease. Thus, treatment with antioxidants can be beneficial for the prevention and therapy of oxidative stress and inflammation in the kidneys resulting from obesity.
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