Neuroimmune Imbalance: The Key for the Treatment of Anxiety?

© 2019 Du J. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License. Anxiety disorder, a common mood disorder, seems associated with neuro-immune aberration on the pathophysiology, revealed by many clinical and preclinical evidences1-5. Furthermore, previous research suggested that the prefrontal cortex (PFC) is a critical brain region involved in anxiety disorders6-9. Now, we show that to keep the balance of pro-inflammatory immune-status and the anti-inflammatory immune-status in the PFC is the key for the treatment of anxiety10.