含磷聚酯自稳定水分散体分散相尺寸的研究

A. Stasiuk, V. I. Lyakh, S. M. Kapatsila, N. Fihurka, V. Samaryk
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引用次数: 0

摘要

合成了以二羧基α-氨基酸的n -衍生物和引入磷酸基的聚氧乙烯系列二醇为基础的新型含磷聚酯,其分散相具有纳米级颗粒,能在水介质中形成自稳定的分散体。在亲水性片段中引入磷酸基团显著提高了稳定能力。新型含磷聚酯的性质使我们可以考虑将其作为潜在的药物输送系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
STUDY OF THE SIZE OF THE DISPERSED PHASE OF SELF-STABILIZED AQUEOUS DISPERSION OF PHOSPHORUS-CONTAINING POLYESTERS
New phosphorus-containing polyesters based on N-derivatives of dicarboxylic α-amino acids and diols of the polyoxyethylene series in which the phosphate group has been introduced are synthesized, capable of forming self-stabilized dispersions with nanosized particles of the dispersed phase in aqueous media. The introduction of the phosphate group in the hydrophilic fragment significantly increases the stabilizing ability. The properties of new phosphorus-containing polyesters allow us to consider them as potential systems for drug delivery.
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