Milan Kettner , Jana Navarová , Gerhard Lebek , Vladimir Krcméry
{"title":"对庆大霉素耐药革兰氏阴性菌氨基糖苷类抗生素的酶修饰","authors":"Milan Kettner , Jana Navarová , Gerhard Lebek , Vladimir Krcméry","doi":"10.1016/S0174-3031(84)80063-3","DOIUrl":null,"url":null,"abstract":"<div><p>An <em>in vitro</em> evaluation of 32 gentamicin-resistant, Gram-negative bacteria from hygiene-centres in Berne, Switzerland and Bratislava, Czechoslovakia, revealed that 24 strains produced gentamicin-modifying enzymes. Occurrence of acetyltransferases (AAC) was confirmed in 16 strains, adenylyltransferase (AAD) /2″/ was observed in 13 strains while 5 of the gentamicin-resistant strains produced both enzymes. All Czechoslovak strains were amikacin-susceptible, in amikacin-resistant <em>Pseudomonas aeruginosa</em> strains from Switzerland the presence of AAC/6′/ was found. In the majority of gentamicin-resistant, netilmicin-susceptible strains the occurrence of AAD/2″/ was observed. Gentamicin-resistance in the modifying enzymes producing strains was due either to production of an acetyltransferase or the adenylyltransferase except Swiss strains of <em>Serratia marcescens</em> where a simultaneous production of both types of the enzymes was noted. Twenty eight strains produced an enzyme modifying animoglycosides of any kind.</p></div>","PeriodicalId":79282,"journal":{"name":"Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...","volume":"257 3","pages":"Pages 372-382"},"PeriodicalIF":0.0000,"publicationDate":"1984-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0174-3031(84)80063-3","citationCount":"3","resultStr":"{\"title\":\"Enzymatic Modification of Aminoglycoside Antibiotics in Gentamicin-Resistant Gram-Negative Bacteria\",\"authors\":\"Milan Kettner , Jana Navarová , Gerhard Lebek , Vladimir Krcméry\",\"doi\":\"10.1016/S0174-3031(84)80063-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>An <em>in vitro</em> evaluation of 32 gentamicin-resistant, Gram-negative bacteria from hygiene-centres in Berne, Switzerland and Bratislava, Czechoslovakia, revealed that 24 strains produced gentamicin-modifying enzymes. Occurrence of acetyltransferases (AAC) was confirmed in 16 strains, adenylyltransferase (AAD) /2″/ was observed in 13 strains while 5 of the gentamicin-resistant strains produced both enzymes. All Czechoslovak strains were amikacin-susceptible, in amikacin-resistant <em>Pseudomonas aeruginosa</em> strains from Switzerland the presence of AAC/6′/ was found. In the majority of gentamicin-resistant, netilmicin-susceptible strains the occurrence of AAD/2″/ was observed. Gentamicin-resistance in the modifying enzymes producing strains was due either to production of an acetyltransferase or the adenylyltransferase except Swiss strains of <em>Serratia marcescens</em> where a simultaneous production of both types of the enzymes was noted. Twenty eight strains produced an enzyme modifying animoglycosides of any kind.</p></div>\",\"PeriodicalId\":79282,\"journal\":{\"name\":\"Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...\",\"volume\":\"257 3\",\"pages\":\"Pages 372-382\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0174-3031(84)80063-3\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0174303184800633\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0174303184800633","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Enzymatic Modification of Aminoglycoside Antibiotics in Gentamicin-Resistant Gram-Negative Bacteria
An in vitro evaluation of 32 gentamicin-resistant, Gram-negative bacteria from hygiene-centres in Berne, Switzerland and Bratislava, Czechoslovakia, revealed that 24 strains produced gentamicin-modifying enzymes. Occurrence of acetyltransferases (AAC) was confirmed in 16 strains, adenylyltransferase (AAD) /2″/ was observed in 13 strains while 5 of the gentamicin-resistant strains produced both enzymes. All Czechoslovak strains were amikacin-susceptible, in amikacin-resistant Pseudomonas aeruginosa strains from Switzerland the presence of AAC/6′/ was found. In the majority of gentamicin-resistant, netilmicin-susceptible strains the occurrence of AAD/2″/ was observed. Gentamicin-resistance in the modifying enzymes producing strains was due either to production of an acetyltransferase or the adenylyltransferase except Swiss strains of Serratia marcescens where a simultaneous production of both types of the enzymes was noted. Twenty eight strains produced an enzyme modifying animoglycosides of any kind.
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