加强依从性咨询对尼日利亚三级卫生机构高病毒载量HIV血清阳性患者病毒载量抑制的影响

Salami Aisha Oluwakemi
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摘要

背景:EAC帮助客户克服依从性障碍,提高抗逆转录病毒治疗的依从性。本研究探讨EAC对病毒载量抑制的作用。方法:本定量研究旨在确定加强依从性咨询(EAC)对尼日利亚阿布贾国防总部医疗中心病毒载量的影响。从医院提取纳入EAC的接受ART治疗的HIV患者的医疗记录进行分析,以确定EAC对项目中患者病毒载量抑制的影响。结果:EAC中近半数(47.6%)的plwhv接受抗逆转录病毒治疗6-10年,42.9%的患者接受抗逆转录病毒治疗10年以上,9.5%的患者接受抗逆转录病毒治疗1 - 5年。76.2%的应答者在ART方案的一线,23.8%的应答者在ART方案的二线。参加EAC的客户中97.6%为世卫组织I期HIV感染,只有一个(2.4%)为IV期。50%的病毒载量检测是由于病毒突变,28.6%是由于未抑制的病毒载量,21.4%的检测是为了监测他们的VL。此外,在有病毒载量结果的33名患者中,14名(42.4%)有非常低水平的病毒血症(1000拷贝/ml)。42.9%参加EAC的原因是服药负担,31.0%是服药频率不规律,19.0%是服药社会问题,2.1%是失访者。关键词:抗逆转录病毒治疗,EAC,病毒载量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Enhance Adherence Counselling on Viral Load Suppression Among High Viral Load HIV Seropositive Patients in a Nigerian Tertiary Health Facility
Background: EAC helps clients overcome adherence hurdles and improve ART adherence. This study examines the effect of EAC on viral load suppression. Method: This quantitative study aims to determine the impacts of enhanced adherence counselling (EAC) on viral load in Defence Headquarters Medical Center, Abuja, Nigeria. The medical records of HIV clients on ART included in EAC were extracted from the hospital and analyzed to determine the impacts of EAC on viral loads suppression of clients in the program. Result: Almost half of the PLWHIV in EAC have been on ART for 6-10 years (47.6%), 42.9% for more than ten years, and 9.5% have been on ART for 1 – 5 years. 76.2% of respondents were on the 1st line of the ART regimen, while 23.8% were on the 2nd line. 97.6% of clients enrolled for EAC were at the WHO stage I HIV infection, and only one (2.4%) was in stage IV. 50% tested for viral load was due to viral blip, 28.6% due to unsuppressed viral load and 21.4% were tested to monitor their VL. Furthermore, of the 33 clients with viral load results, 14 (42.4%) had very low-level viremia (<50 copies/ml), 10 (30.3%) had low-level viremia (50–1000 copies/ml), but 9 (27.3%) still had high-level viremia (>1000 copies/ml). 42.9% enrolled for EAC because of pill burdens, 31.0% due to irregular dosing frequency, 19.0% because of pill social problems, and 2.1% were people lost to follow-up returned.. Keywords: Antiretroviral therapy, EAC, Viral load.
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