细胞毒性药物的超灵敏生物分析测定:重点是局部给药的抗癌药物

L. Vainchtein, H. Rosing, J. Schellens, J. Beijnen
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引用次数: 1

摘要

研究了局部给药途径,以减少细胞毒性药物的全身毒性和增加局部疗效。局部给药策略的一些例子是皮肤、腹腔、鞘内和膀胱内化疗。局部给药时,局部药物浓度高,局部疗效高,有条件地只有少量药物被吸收到血液中,全身毒性低。我们的主要目的是对超灵敏生物分析方法的可用性进行盘点和评论,这些方法可以确定可能进入血液的药物痕迹,例如局部应用后,可能导致全身毒性。我们得出的结论是,在过去的几年中,多种超灵敏的测定已经设计能够定量地确定非常低水平的细胞毒性制剂,例如,在局部给药后系统达到。大多数方法是基于串联质谱联用液相色谱检测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ultrasensitive Bioanalytical Assays for Cytotoxic Drugs: Focus on Locally Administered Anti-Cancer Agents
Local administration routes have been investigated to reduce the systemic toxicity and to increase the local ef- ficacy of cytotoxic drugs. Some examples of local administration strategies are cutaneous, intraperitoneal, intrathecal and intravesical chemotherapy. When administered locally, high local drug concentrations can be achieved with increased lo- cal efficacy and, conditionally that only small amounts of drug are absorbed into the bloodstream, low systemic toxicity. Our main purpose is to make an inventory and to comment on the availability of ultrasensitive bioanalytical assays that could determine traces of the drugs that may have passed into the bloodstream, e.g. after local application, and which may lead to the systemic toxicity. We conclude that in the last years, multiple ultrasensitive assays have been designed capable to quantitatively determine very low levels of cytotoxic agents e.g. systemically reached after local administration. Most methods are based on the hyphenated liquid chromatography with tandem mass spectrometric detection.
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