孟加拉国儿童和青少年1型糖尿病患者血清镁水平及其与血糖控制的关系

Shawana Haque, M. Muttalib, A. Nesa, N. Uddin, S. Hossain, Thahamina Shahabuddin, A. Tasnim
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引用次数: 0

摘要

1型糖尿病是儿童和青少年中最常见的内分泌和代谢疾病之一。血镁水平的改变可能与代谢控制和糖尿病并发症有关。本研究旨在探讨1型糖尿病儿童及青少年血清镁水平及其与血糖控制的关系。在这项研究中,80名年龄在1至18岁的1型糖尿病儿童和青少年,以及80名年龄匹配的健康对照者,来自达卡总医院糖尿病、内分泌和代谢紊乱研究与康复研究所儿童糖尿病变化门诊。采用横断面设计,我们测量了所有研究对象的人体测量参数和血清镁水平。我们还估计了糖尿病儿童、青少年和对照组的空腹血糖和HbA1c水平。1型糖尿病患者血清镁水平的平均值±SD明显低于对照组(0.7±0.1 vs 0.8±0.1 mmol/L);P = < 0.001)。血糖控制较差的受试者镁水平低于血糖控制良好的受试者(分别为0.6±0.1 mmol/L和0.8±0.1 mmol/L);P = < 0.001)。该研究表明,1型糖尿病儿童和青少年的血清镁水平较低,这与血糖控制不良密切相关,这可能导致糖尿病并发症的早期发展。孟加拉国医学杂志2019年9月;48 (3): 16-20
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Status of Serum Magnesium Level in Bangladeshi Children and Adolescents with Type 1 Diabetes Mellitus and its Relationship with Glycemic Control
Type 1 diabetes mellitus is one of the most common endocrine and metabolic disorder in children and adolescents. Alteration of serum magnesium level may be associated with metabolic control and diabetic complications. The aim of the study was to evaluate serum magnesium level and find out its relationship with glycemic control in type 1 diabetic children and adolescents. For this study 80 type 1 diabetic children & adolescents with age range 1 to 18 years and 80 aged matched healthy controls were enrolled from the outpatient department of Changing Diabetes in Children, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine & Metabolic disorders, General Hospital, Dhaka. Using a cross sectional design, we measured anthropometric parameters and serum magnesium level of all study subjects. We also estimate the fasting plasma glucose and HbA1c levels of the diabetic children and adolescents and controls. The mean ± SD of serum magnesium level was significantly lower in patient with type 1 DM compared to control (0.7 ± 0.1 vs 0.8 ± 0.1 mmol/L respectively; p= < 0.001). Lower level of magnesium was found in subjects with poor glycemic control compared to good glycemic control (0.6 ± 0.1 vs 0.8 ± 0.1 mmol/L respectively; p= < 0.001). This study showed that serum magnesium level was lowered  in type 1 diabetic children and adolescents and it was strongly associated with poor glycemic control which potentially contributing to the early development of diabetic complications. Bangladesh Med J. 2019 Sep; 48 (3): 16-20
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