黄芪精油潜在的抗炎活性

IF 2.2 3区农林科学 Q3 CHEMISTRY, APPLIED

Journal of Essential Oil Research Pub Date : 2022-09-05 DOI:10.1080/10412905.2022.2118878

A. Alqudah, R. AbuDalo, E. Qnais, Mohammaed Wedyan, Taima Qudah, Muna Oqal

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引用次数: 0

摘要

摘要:本研究旨在探讨黑线Anastatica hierochuntica精油的抗炎活性及其可能的抗炎机制。采用水蒸气蒸馏法提取挥发油，并用气相色谱和质谱(GC/MS)对挥发油进行分析。采用经典炎症模型(卡拉胶诱导的足跖水肿和腹膜炎)评估其抗炎活性。测定其对一氧化氮自由基的清除活性和脂质过氧化作用，以评价其抗氧化活性。EOAH主要由孜然醛(33.8%)、反式β-石竹烯(32.5%)和芳樟醇(8.2%)组成。EOAH可显著降低卡拉胶诱导的水肿、腹膜炎、髓过氧化物酶活性和一氧化氮-腹膜灌洗浓度。此外，硝普钠生成的一氧化氮自由基被精油显著抑制。此外，EOAH还能防止Fe+2-或Fe+2 + h2o2诱导的脂质过氧化。综上所述，EOAH具有抗炎活性，可能与其抗氧化能力有关。

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Potential anti-inflammatory activity of the Anastatica hierochuntica essential oil

ABSTRACT The aims of this study were to evaluate the anti-inflammatory activity and the possible anti-inflammatory mechanisms of Anastatica hierochuntica essential oil (EOAH). The essential oils were obtained by hydrodistillation of the aerial parts of the plant, and analyzed using gas chromatography and mass spectrometry (GC/MS). Their anti-inflammatory activity was evaluated using classical model of inflammation (carrageenan-induced paw edema and peritonitis). Nitric oxide radical-scavenging activity and lipid peroxidation were determined to assess the antioxidant activity of the essential oil. The EOAH mainly comprised Cuminaldehyde (33.8%), trans-β-Caryophyllene (32.5%), and Linalool (8.2%). EOAH significantly reduced edema, peritonitis, myeloperoxidase activity, and NOx-peritoneal lavage concentration induced by carrageenan. In addition, nitric oxide radical generated from sodium nitroprusside was significantly inhibited by the essential oil. Furthermore, EOAH was able to prevent Fe+2- or Fe+2 plus H2O2-induced lipid peroxidation. In conclusion, the EOAH exerts anti-inflammatory activity that could be related to its antioxidant capacity.

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来源期刊

Journal of Essential Oil Research 工程技术-食品科技

CiteScore

6.00

自引率

3.30%

发文量

审稿时长

18-36 weeks

期刊介绍： Journal of Essential Oil Research ( JEOR) is the major forum for the publication of essential oil research and analysis. Each issue includes studies performed on the chemical composition of some of the 20,000 aromatic plants known in the plant kingdom. JEOR is devoted entirely to all phases of research from every corner of the world by the experts in their field. JEOR''s main areas of focus include: -Analytical chemistry- Biological activity- Biotechnology- Chemical composition- Chemical synthesis- Chemosystematics- Microbiological activity- Plant biochemistry/biosynthesis- Toxicology. Published six times per year, JEOR provides articles on the aromatic principles of a plant or its isolates and are directed toward furthering our readers'' knowledge of the aromatic plant and animal kingdoms.