高甘油三酯血症与缺血性脑卒中的关系

Bangladesh Journal of Neuroscience Pub Date : 2016-01-31 DOI:10.3329/bjn.v32i1.57411

B. Das, K. J. Mondal

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引用次数: 0

摘要

中风是发病和死亡的主要原因之一，也是一项社会经济挑战。对于像孟加拉国这样的发展中国家来说尤其如此，在这些国家，包括康复系统在内的卫生支持系统不是普通人能够获得的。高甘油三酯血症在缺血性脑卒中(IS)发病机制中有重要影响。因此，本研究的重点是评估和评估IS患者血清甘油三酯水平的相关性。本病例对照研究于2011年7月至2013年6月在达卡BSMMU神经内科与生物化学系合作进行。在这项研究中，60例诊断为缺血性脑卒中的患者和60例年龄和性别匹配的健康对照。评估缺血性卒中(IS)患者与健康成人的危险因素(校正优势比)。在这项研究中，结婚[或。1.95, 95%可信区间(0.40 - -9.42),p = 0.409),吸烟者(OR.1.65, 95%可信区间(0.57 - 4.82),p = 0.357), DM(或。1.48, 95% CI (0.36-6.06)， p=0.582]， IHD [OR。1.51, 95% CI (0.29 - 7.89)， p=0.624]， HTN [OR。3.66, 95% CI (1.11-12.12)， p=0.033]，超重[OR.2.31, 95% CI(0.77 - 6.91)， 0.135]和肥胖[OR. 3.66, 95% CI (1.11-12.12)， p=0.033]。16.19, 95% CI (1.31 ~ 200.6)， p=0.030]，血清TC升高[OR = 8.24, 95% CI (2.07 ~ 32.83)， p=0.003]， TG升高[OR =0.003]。9.40, 95% CI (1.17 -75.86)， p=0.035]， LDL [OR。0.45, 95% CI (0.10-2.05)， p=0.308]， HDL水平降低[OR。3.37, 95% CI (1.03 ~ 12.25)， p=0.045]是发生IS的危险因素。通过独立t检验，发现病例与对照组血脂等连续变量差异有统计学意义。研究重点TG的SD均值在病例组为237.67(61.74)，对照组为169.97(26.95)，差异有高度统计学意义(p < 0.0001)。所有显著变量均进入逐步logistic回归分析模型。通过logistic回归模型，最终得出高血压、肥胖、TC水平升高、TG水平升高、HDL水平降低是IS发生的有统计学意义的危险因素。孟加拉国神经科学杂志2016;Vol. 32 (1): 34-38

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Association of Hypertriglycerideamia with Ischaemic Stroke

Stroke is one of the foremost causes of morbidity, mortality and is a socioeconomic challenge. This is particularly true for developing countries like Bangladesh, where health support system including the rehabilitation system is not within the reach of common people. Hypertriglycerademia has an effective influence in the pathogenesis of Ischaemic Stroke (IS). So, the focus of this study was to evaluate and assess the association of serum triglyceride level in patients of IS. This case control study was carried out in the Department of Neurology in collaboration with Department of Biochemistry, BSMMU, Dhaka from July 2011 to June 2013. In this study, 60 diagnosed cases of ischaemic stroke patients and 60 age and sex matched healthy controls were enrolled. Risk factors of Ischemic Stroke (IS) patients were assessed ( adjusted Odds Ratio) in comparison with healthy adults. In this study, being married [OR. 1.95, 95% CI (0.40-9.42), p=0.409] , smoker [OR.1.65, 95% CI (0.57 - 4.82),p= 0.357], DM [OR. 1.48, 95% CI (0.36-6.06), p=0.582 ], IHD [OR. 1.51, 95% CI (0.29 – 7.89), p=0.624] , HTN [OR. 3.66, 95% CI (1.11–12.12), p=0.033] , overweight [OR.2.31, 95% CI (0.77 – 6.91), 0.135] and obesity [OR. 16.19, 95% CI (1.31–200.6), p=0.030] , increased level of serum TC [OR.8.24, 95% CI (2.07 – 32.83), p=0.003], TG [OR. 9.40, 95% CI (1.17 -75.86), p=0.035], LDL [OR. 0.45, 95% CI (0.10–2.05), p=0.308],and decreased level of HDL [OR. 3.37, 95% CI (1.03 - 12.25), p=0.045] were found as risk factors in developing IS. Independent t-test was done to find out the statistically significant differences of continuous variables like serum lipid profile between case and control group. The mean (SD) value of TG which is focus of this study, was found 237.67 (61.74) in case group, and 169.97 (26.95) in control group which was highly statistically significant (p < 0.0001). All of the significant variables were entered into stepwise logistic regression analysis model. From the logistic regression model, it can be finally concluded that hypertension, obesity, increased level of TC, increased level of TG and decreased level of HDL were statistically significant risk factors for development of IS. Bangladesh Journal of Neuroscience 2016; Vol. 32 (1): 34-38

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Bangladesh Journal of Neuroscience

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