Hakan Tekgüç, S. Aksoylar, Doğa Ceren Tekgüç, S. Kansoy
{"title":"儿童同种异体干细胞移植的嵌合分析及其对生存的影响","authors":"Hakan Tekgüç, S. Aksoylar, Doğa Ceren Tekgüç, S. Kansoy","doi":"10.4274/cjms.2022.2021-215","DOIUrl":null,"url":null,"abstract":"the only curative treatment for many congenital and acquired, malignant and non-malignant diseases of the childhood Donor cell engraftment is a critical step in the success of Allo-HSCT. However, engraftment does not always result in a definite status and we may end up with mixed chimerism. Mixed chimerism is a state where both the recipient and donor hematopoietic stem cells coexist in the host’s bone marrow. 4 Although malignancies by -3.04 (-4.00 to -2.08) [hazard ratio (HR): 0.05 (p<0.001)]. Neutrophil engraftment was the other factor which was positively correlated with EFS (HR p-value: 0.05) CONCLUSION: There is a positive correlation between CS in the first 100 days and EFS for both malignant and non-malignant diseases.","PeriodicalId":41370,"journal":{"name":"Cyprus Journal of Medical Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.3000,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chimerism Analysis of Children with Allogeneic Stem-Cell transplantation and Its Effect on Survival\",\"authors\":\"Hakan Tekgüç, S. Aksoylar, Doğa Ceren Tekgüç, S. Kansoy\",\"doi\":\"10.4274/cjms.2022.2021-215\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"the only curative treatment for many congenital and acquired, malignant and non-malignant diseases of the childhood Donor cell engraftment is a critical step in the success of Allo-HSCT. However, engraftment does not always result in a definite status and we may end up with mixed chimerism. Mixed chimerism is a state where both the recipient and donor hematopoietic stem cells coexist in the host’s bone marrow. 4 Although malignancies by -3.04 (-4.00 to -2.08) [hazard ratio (HR): 0.05 (p<0.001)]. Neutrophil engraftment was the other factor which was positively correlated with EFS (HR p-value: 0.05) CONCLUSION: There is a positive correlation between CS in the first 100 days and EFS for both malignant and non-malignant diseases.\",\"PeriodicalId\":41370,\"journal\":{\"name\":\"Cyprus Journal of Medical Sciences\",\"volume\":\"11 1\",\"pages\":\"\"},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2022-10-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cyprus Journal of Medical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4274/cjms.2022.2021-215\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cyprus Journal of Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/cjms.2022.2021-215","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Chimerism Analysis of Children with Allogeneic Stem-Cell transplantation and Its Effect on Survival
the only curative treatment for many congenital and acquired, malignant and non-malignant diseases of the childhood Donor cell engraftment is a critical step in the success of Allo-HSCT. However, engraftment does not always result in a definite status and we may end up with mixed chimerism. Mixed chimerism is a state where both the recipient and donor hematopoietic stem cells coexist in the host’s bone marrow. 4 Although malignancies by -3.04 (-4.00 to -2.08) [hazard ratio (HR): 0.05 (p<0.001)]. Neutrophil engraftment was the other factor which was positively correlated with EFS (HR p-value: 0.05) CONCLUSION: There is a positive correlation between CS in the first 100 days and EFS for both malignant and non-malignant diseases.
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