口服表达幽门螺杆菌中性粒细胞活化蛋白的重组枯草芽孢杆菌孢子通过上调Tregs抑制花生过敏

Clinical & Experimental Allergy Pub Date : 2019-12-01 DOI:10.1111/cea.13489

Jialiang Mai, Bingshao Liang, Zhile Xiong, Xiaolan Ai, F. Gao, Y. Long, Shuwen Yao, Yunfeng Liu, S. Gong, Zhenwen Zhou

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引用次数: 7

摘要

幽门螺杆菌中性粒细胞活化蛋白(NAP)是一种具有抗Th2炎症活性的免疫调节剂，可用于预防IgE介导的过敏反应。霍乱毒素B (CTB)是一种能诱导抗原耐受的粘膜佐剂。枯草芽孢杆菌孢子是口服递送异源抗原的理想载体。

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Oral administration of recombinant Bacillus subtilis spores expressing Helicobacter pylori neutrophil‐activating protein suppresses peanut allergy via up‐regulation of Tregs

Helicobacter pylori neutrophil‐activating protein (NAP) is an immune modulator with anti‐Th2 inflammation activity that can be used to prevent IgE‐mediated allergic reactions. Cholera toxin B (CTB) is a mucosal adjuvant that can induce antigen tolerance. Bacillus subtilis spores are an ideal vehicle for the oral delivery of heterologous antigens.

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Clinical & Experimental Allergy

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