{"title":"韩国淫羊藿Icariside II对肿瘤细胞的体外作用","authors":"Xin Lin, Wen‐kui Li, P. Xiao","doi":"10.1211/146080899128734424","DOIUrl":null,"url":null,"abstract":"Epimedium koreanum is one of the most popular medicinal plants in China, its major constituents being 8-prenyl flavonoids. We studied the effects of one of these flavonoids, icariside II (3, 5, 7-trihydroxy-4′-methoxyflavone-3-O-α-L-rhamnopyranoside) on the invitro growth of five human tumour cell lines, human promyelocytic leukaemia HL-60, human erythroleukaemia K562, human nasopharyngeal carcinoma cell KB, macrophage of human pulmonary carcinoma cell PG and human gastric carcinoma cell BGC, using the MTT assay. \n \n \n \nIcariside II was cytotoxic to all cell lines tested. The inhibition (53–88%) observed was at 10−5M. \n \n \n \nThe results suggest that icariside II may be a potentially useful antitumour agent.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Effects of Icariside II from Epimedium koreanum on Tumour Cell Lines In‐vitro\",\"authors\":\"Xin Lin, Wen‐kui Li, P. Xiao\",\"doi\":\"10.1211/146080899128734424\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Epimedium koreanum is one of the most popular medicinal plants in China, its major constituents being 8-prenyl flavonoids. We studied the effects of one of these flavonoids, icariside II (3, 5, 7-trihydroxy-4′-methoxyflavone-3-O-α-L-rhamnopyranoside) on the invitro growth of five human tumour cell lines, human promyelocytic leukaemia HL-60, human erythroleukaemia K562, human nasopharyngeal carcinoma cell KB, macrophage of human pulmonary carcinoma cell PG and human gastric carcinoma cell BGC, using the MTT assay. \\n \\n \\n \\nIcariside II was cytotoxic to all cell lines tested. The inhibition (53–88%) observed was at 10−5M. \\n \\n \\n \\nThe results suggest that icariside II may be a potentially useful antitumour agent.\",\"PeriodicalId\":19946,\"journal\":{\"name\":\"Pharmacy and Pharmacology Communications\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacy and Pharmacology Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1211/146080899128734424\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacy and Pharmacology Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1211/146080899128734424","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
摘要
韩国淫羊藿(Epimedium koreanum)是中国最受欢迎的药用植物之一，其主要成分为8-戊烯基黄酮类化合物。采用MTT法研究了其中一种黄酮类化合物红糖苷II(3,5,7 -三羟基-4′-甲氧基黄酮-3- o -α- l -鼠李糖苷)对人早幼粒细胞白血病HL-60、人红细胞白血病K562、人鼻咽癌细胞KB、人肺癌细胞PG巨噬细胞和人胃癌细胞BGC五种肿瘤细胞系体外生长的影响。Icariside II对所有细胞系均有细胞毒性。10−5M时，抑制率为53 ~ 88%。结果表明，icariside II可能是一种潜在的有用的抗肿瘤药物。
Effects of Icariside II from Epimedium koreanum on Tumour Cell Lines In‐vitro
Epimedium koreanum is one of the most popular medicinal plants in China, its major constituents being 8-prenyl flavonoids. We studied the effects of one of these flavonoids, icariside II (3, 5, 7-trihydroxy-4′-methoxyflavone-3-O-α-L-rhamnopyranoside) on the invitro growth of five human tumour cell lines, human promyelocytic leukaemia HL-60, human erythroleukaemia K562, human nasopharyngeal carcinoma cell KB, macrophage of human pulmonary carcinoma cell PG and human gastric carcinoma cell BGC, using the MTT assay.
Icariside II was cytotoxic to all cell lines tested. The inhibition (53–88%) observed was at 10−5M.
The results suggest that icariside II may be a potentially useful antitumour agent.
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