混合柠檬酸-磺胺甲恶唑Mn(II)、Fe(III)和Ni (II)配合物的合成、表征及抗菌活性

A. Lawal, S. Olowude, A. O. Rajee, S. Elaigwu, M. Bamigboye, Haizat O. Saadu, Amos Mamman, Halimat F. Babamale, M. T. Yunus-Issa, S. A. Amolegbe
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引用次数: 0

摘要

摘要以Mn(II)、Fe(III)和Ni(II)为氯化物,合成了三种磺胺甲恶唑与柠檬酸的混合配体配合物。通过元素分析、熔点、电导率、磁测、紫外可见光谱和红外光谱对配合物进行了表征。红外光谱数据表明,配体呈双齿状,柠檬酸通过羧基的C=O和羟基的氧来配位,而磺胺甲恶唑通过伯胺基的氮原子和亚砜基的O=S=O来配位。元素分析的结果与所提出的配合物模式一致,而熔点测定证实合成的化合物是纯的。采用Muller Hinton扩散法筛选金属配合物对铜绿假单胞菌g(+)、大肠杆菌g(+)、肺炎克雷伯菌g(+)、金黄色葡萄球菌g(+)和念珠菌g(+) 5株细菌微生物的抑菌活性。结果表明,对细菌分离物的整体抑制区依次为Fe(III)→Ni(II)→Mn(II)配合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mn(II), Fe(III) and Ni (II) Complexes of Mixed Citric acid - Sulphamethoxazole: Synthesis, Characterization and Antibacterial activity
Abstract Three mixed ligand complexes of sulphamethoxazole and citric acid have been synthesized using Mn(II), Fe(III) and Ni(II) chlorides. The complexes were characterized by elemental analysis, melting point, conductivity test, magnetic measurement, UV-Visible and infrared spectroscopy. The infrared spectra data revealed that the ligands act as bidentate, in which citric acid coordinate through C=O of the carboxyl and oxygen of the hydroxyl groups, while sulphamethoxazole coordinates through nitrogen atom of the primary amine group and O=S=O of the sulphonyl group. The result of the elemental analysis was consistent with the proposed pattern for the complexes, while the melting point determination confirmed that the synthesized compounds were pure. Antibacterial activity of metal complexes were screening against five strain bacteria microorganism of g(+)Pseudomonas aeruginosa, Eschericia coli, g(+)Klebsiella pneumonia, g(+)Staphylococcus aureus and g(+)Candida using Muller Hinton diffusion method. The result showed that the overall zone of inhibition against bacterial isolate follows an increasing order of priority Fe(III)˃ Ni(II)˃ Mn(II) complexes.
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