Nguyen Minh Tri, V. N. Toan, H. M. Linh, Ngô Thị Thanh Mai, Tran Thi-Hai-Yen, Ngo Thi Thuy, Nguyen Thi Thu Huong, Pham Thi Thuy Van, T. P. H. Yen, Nguyen Thi Quynh Giang, H. T. Van, N. Thanh
{"title":"一些1 ω-烷烃取代(Un)取代异黄酮及其产物与叠氮化钠的反应","authors":"Nguyen Minh Tri, V. N. Toan, H. M. Linh, Ngô Thị Thanh Mai, Tran Thi-Hai-Yen, Ngo Thi Thuy, Nguyen Thi Thu Huong, Pham Thi Thuy Van, T. P. H. Yen, Nguyen Thi Quynh Giang, H. T. Van, N. Thanh","doi":"10.3390/ecsoc-25-11716","DOIUrl":null,"url":null,"abstract":": Azide derivatives of isatins were the initial materials needed for click chemistry, so as to form 1,2,3-triazoles in order to synthesize the hybrid compounds of 1,2,3-triazole–isatin with monosaccharide moieties. The required substituted isatins were prepared according to the Sandmeyer method from corresponding substituted anilines. N -( ω -bromoalkyl) isatins were prepared through the nucleophilic reaction, S N 2, of (un)substituted isatins with appropriate dibromoalkanes. Some ω -azidoalkylisatins were synthesized by the reaction of corresponding ω -bromoalkylisatins with sodium azide. The reactions were performed in dry DMF as solvents in the presence of K 2 CO 3 as the base and KI as the promoting agent. The product yields reached 30–85%.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reaction of Some Substituted (Un)Substituted Isatins with 1,ω-Alkanes and Their Products with Sodium Azide\",\"authors\":\"Nguyen Minh Tri, V. N. Toan, H. M. Linh, Ngô Thị Thanh Mai, Tran Thi-Hai-Yen, Ngo Thi Thuy, Nguyen Thi Thu Huong, Pham Thi Thuy Van, T. P. H. Yen, Nguyen Thi Quynh Giang, H. T. Van, N. Thanh\",\"doi\":\"10.3390/ecsoc-25-11716\",\"DOIUrl\":null,\"url\":null,\"abstract\":\": Azide derivatives of isatins were the initial materials needed for click chemistry, so as to form 1,2,3-triazoles in order to synthesize the hybrid compounds of 1,2,3-triazole–isatin with monosaccharide moieties. The required substituted isatins were prepared according to the Sandmeyer method from corresponding substituted anilines. N -( ω -bromoalkyl) isatins were prepared through the nucleophilic reaction, S N 2, of (un)substituted isatins with appropriate dibromoalkanes. Some ω -azidoalkylisatins were synthesized by the reaction of corresponding ω -bromoalkylisatins with sodium azide. The reactions were performed in dry DMF as solvents in the presence of K 2 CO 3 as the base and KI as the promoting agent. The product yields reached 30–85%.\",\"PeriodicalId\":11441,\"journal\":{\"name\":\"ECSOC-25\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-11-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ECSOC-25\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/ecsoc-25-11716\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ECSOC-25","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/ecsoc-25-11716","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Reaction of Some Substituted (Un)Substituted Isatins with 1,ω-Alkanes and Their Products with Sodium Azide
: Azide derivatives of isatins were the initial materials needed for click chemistry, so as to form 1,2,3-triazoles in order to synthesize the hybrid compounds of 1,2,3-triazole–isatin with monosaccharide moieties. The required substituted isatins were prepared according to the Sandmeyer method from corresponding substituted anilines. N -( ω -bromoalkyl) isatins were prepared through the nucleophilic reaction, S N 2, of (un)substituted isatins with appropriate dibromoalkanes. Some ω -azidoalkylisatins were synthesized by the reaction of corresponding ω -bromoalkylisatins with sodium azide. The reactions were performed in dry DMF as solvents in the presence of K 2 CO 3 as the base and KI as the promoting agent. The product yields reached 30–85%.