一些1 ω-烷烃取代(Un)取代异黄酮及其产物与叠氮化钠的反应

ECSOC-25 Pub Date : 2021-11-14 DOI:10.3390/ecsoc-25-11716
Nguyen Minh Tri, V. N. Toan, H. M. Linh, Ngô Thị Thanh Mai, Tran Thi-Hai-Yen, Ngo Thi Thuy, Nguyen Thi Thu Huong, Pham Thi Thuy Van, T. P. H. Yen, Nguyen Thi Quynh Giang, H. T. Van, N. Thanh
{"title":"一些1 ω-烷烃取代(Un)取代异黄酮及其产物与叠氮化钠的反应","authors":"Nguyen Minh Tri, V. N. Toan, H. M. Linh, Ngô Thị Thanh Mai, Tran Thi-Hai-Yen, Ngo Thi Thuy, Nguyen Thi Thu Huong, Pham Thi Thuy Van, T. P. H. Yen, Nguyen Thi Quynh Giang, H. T. Van, N. Thanh","doi":"10.3390/ecsoc-25-11716","DOIUrl":null,"url":null,"abstract":": Azide derivatives of isatins were the initial materials needed for click chemistry, so as to form 1,2,3-triazoles in order to synthesize the hybrid compounds of 1,2,3-triazole–isatin with monosaccharide moieties. The required substituted isatins were prepared according to the Sandmeyer method from corresponding substituted anilines. N -( ω -bromoalkyl) isatins were prepared through the nucleophilic reaction, S N 2, of (un)substituted isatins with appropriate dibromoalkanes. Some ω -azidoalkylisatins were synthesized by the reaction of corresponding ω -bromoalkylisatins with sodium azide. The reactions were performed in dry DMF as solvents in the presence of K 2 CO 3 as the base and KI as the promoting agent. The product yields reached 30–85%.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reaction of Some Substituted (Un)Substituted Isatins with 1,ω-Alkanes and Their Products with Sodium Azide\",\"authors\":\"Nguyen Minh Tri, V. N. Toan, H. M. Linh, Ngô Thị Thanh Mai, Tran Thi-Hai-Yen, Ngo Thi Thuy, Nguyen Thi Thu Huong, Pham Thi Thuy Van, T. P. H. Yen, Nguyen Thi Quynh Giang, H. T. Van, N. Thanh\",\"doi\":\"10.3390/ecsoc-25-11716\",\"DOIUrl\":null,\"url\":null,\"abstract\":\": Azide derivatives of isatins were the initial materials needed for click chemistry, so as to form 1,2,3-triazoles in order to synthesize the hybrid compounds of 1,2,3-triazole–isatin with monosaccharide moieties. The required substituted isatins were prepared according to the Sandmeyer method from corresponding substituted anilines. N -( ω -bromoalkyl) isatins were prepared through the nucleophilic reaction, S N 2, of (un)substituted isatins with appropriate dibromoalkanes. Some ω -azidoalkylisatins were synthesized by the reaction of corresponding ω -bromoalkylisatins with sodium azide. The reactions were performed in dry DMF as solvents in the presence of K 2 CO 3 as the base and KI as the promoting agent. The product yields reached 30–85%.\",\"PeriodicalId\":11441,\"journal\":{\"name\":\"ECSOC-25\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-11-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ECSOC-25\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/ecsoc-25-11716\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ECSOC-25","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/ecsoc-25-11716","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

: isatins的叠氮化物衍生物是点击化学生成1,2,3-三唑所需的初始材料,从而合成1,2,3-三唑- isatin的单糖杂化化合物。以相应的取代苯胺为原料,根据Sandmeyer法制备了所需的取代isatins。N -(ω -溴烷基)异黄酮通过(非)取代异黄酮与合适的二溴烷烃进行ns2亲核反应制备。将相应的ω -溴化烷基化蛋白与叠氮化钠反应合成了若干ω -叠氮化烷基化蛋白。反应以干燥的DMF为溶剂,以k2co3为碱,KI为促进剂进行。产品收率达到30-85%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reaction of Some Substituted (Un)Substituted Isatins with 1,ω-Alkanes and Their Products with Sodium Azide
: Azide derivatives of isatins were the initial materials needed for click chemistry, so as to form 1,2,3-triazoles in order to synthesize the hybrid compounds of 1,2,3-triazole–isatin with monosaccharide moieties. The required substituted isatins were prepared according to the Sandmeyer method from corresponding substituted anilines. N -( ω -bromoalkyl) isatins were prepared through the nucleophilic reaction, S N 2, of (un)substituted isatins with appropriate dibromoalkanes. Some ω -azidoalkylisatins were synthesized by the reaction of corresponding ω -bromoalkylisatins with sodium azide. The reactions were performed in dry DMF as solvents in the presence of K 2 CO 3 as the base and KI as the promoting agent. The product yields reached 30–85%.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信